Quinazoline-based VEGFR-2 inhibitors as potential anti-angiogenic agents: A contemporary perspective of SAR and molecular docking studies
M Moradi, A Mousavi, Z Emamgholipour… - European Journal of …, 2023 - Elsevier
Angiogenesis, the formation of new blood vessels from the existing vasculature, is pivotal in
the migration, growth, and differentiation of endothelial cells in normal physiological …
the migration, growth, and differentiation of endothelial cells in normal physiological …
Modified benzoxazole-based VEGFR-2 inhibitors and apoptosis inducers: Design, synthesis, and anti-proliferative evaluation
This work is one of our efforts to discover potent anticancer agents. We modified the most
promising derivative of our previous work concerned with the development of VEGFR-2 …
promising derivative of our previous work concerned with the development of VEGFR-2 …
Evaluation of the anti-proliferative activity of 2-oxo-pyridine and 1′ H-spiro-pyridine derivatives as a new class of EGFR Wt and VEGFR-2 inhibitors with apoptotic …
RR Raslan, YA Ammar, SA Fouad, SA Hessein… - RSC …, 2023 - pubs.rsc.org
Developing new agents for cancer treatment remains a top priority because it is one of the
deadliest worldwide. A new series of 2-oxo-pyridine and 1′ H-spiro-pyridine derivatives …
deadliest worldwide. A new series of 2-oxo-pyridine and 1′ H-spiro-pyridine derivatives …
Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: in vitro and in silico studies
Abstract New nicotinamide derivatives 6, 7, 10, and 11 were designed and synthesised
based on the essential features of the VEGFR-2 inhibitors. Compound 10 revealed the …
based on the essential features of the VEGFR-2 inhibitors. Compound 10 revealed the …
Novel promising benzoxazole/benzothiazole‐derived immunomodulatory agents: Design, synthesis, anticancer evaluation, and in silico ADMET analysis
Eleven novel benzoxazole/benzothiazole‐based thalidomide analogs were designed and
synthesized to obtain new effective antitumor immunomodulatory agents. The synthesized …
synthesized to obtain new effective antitumor immunomodulatory agents. The synthesized …
[HTML][HTML] Green synthesis and molecular docking study of some new thiazoles using terephthalohydrazide chitosan hydrogel as ecofriendly biopolymeric catalyst
Terephthalohydrazide chitosan hydrogel (TCs) was prepared and investigated as an
ecofriendly biopolymeric catalyst for synthesis of some novel thiazole and thiadiazole …
ecofriendly biopolymeric catalyst for synthesis of some novel thiazole and thiadiazole …
Recent Advances in Structural Optimization of Quinazoline-Based Protein Kinase Inhibitors for Cancer Therapy (2021–Present)
HT Abdel-Mohsen, MM Anwar, NS Ahmed… - Molecules, 2024 - mdpi.com
Cancer is a complicated, multifaceted disease that can impact any organ in the body.
Various chemotherapeutic agents have a low selectivity and are very toxic when used alone …
Various chemotherapeutic agents have a low selectivity and are very toxic when used alone …
Design, synthesis, and biological evaluation of novel bioactive thalidomide analogs as anticancer immunomodulatory agents
Cancer is still a dangerous disease with a high mortality rate all over the world. In our
attempt to develop potential anticancer candidates, new quinazoline and phthalazine based …
attempt to develop potential anticancer candidates, new quinazoline and phthalazine based …
Immunomodulatory quinazoline-based thalidomide analogs: Design, synthesis, apoptosis and anticancer evaluations
AE Abdallah, IH Eissa, ABM Mehany, H Sakr… - Journal of Molecular …, 2023 - Elsevier
In our effort to discover potential immunomodulatory anticancer candidates, a new series of
quinazolinone derivatives carrying glutarimide moiety were designed and synthesized as …
quinazolinone derivatives carrying glutarimide moiety were designed and synthesized as …
Design, synthesis and anticancer activity of novel 2-arylbenzimidazole/2-thiopyrimidines and 2-thioquinazolin-4 (3H)-ones conjugates as targeted RAF and VEGFR-2 …
IH Ali, HT Abdel-Mohsen, MM Mounier… - Bioorganic …, 2022 - Elsevier
In the current study, series of 2-arylbenzimidazole-thiopyrimidine and-thioquinazolin-4 (3H)-
ones conjugates 12a-d, 13a, b and 14a-l have been synthesized. All the synthesized …
ones conjugates 12a-d, 13a, b and 14a-l have been synthesized. All the synthesized …