Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …

Lipid droplets are dynamic organelles that store neutral lipids, serve the metabolic needs of
cells, and sequester lipids to prevent lipotoxicity and membrane damage. Here we review …

Dietary mono-unsaturated fatty acids (MUFAs) are linked to longevity in several species. But
the mechanisms by which MUFAs extend lifespan remain unclear. Here we show that an …

TMEM41B and VMP1 are integral membrane proteins of the endoplasmic reticulum (ER)
and regulate the formation of autophagosomes, lipid droplets (LDs), and lipoproteins …

Lipid droplets, also known as oil bodies or lipid bodies, are plant organelles that
compartmentalize neutral lipids as a hydrophobic matrix covered by proteins embedded in a …

We describe a general method that allows structure determination of small proteins by single-
particle cryo-electron microscopy (cryo-EM). The method is based on the availability of a …

After having been disregarded for a long time as inert fat drops, lipid droplets (LDs) are now
recognized as ubiquitous cellular organelles with key functions in lipid biology and beyond …

Cryo-electron tomography (cryo-ET) allows for label-free high-resolution imaging of
macromolecular assemblies in their native cellular context. However, the localization of …

All living organisms can make lipid droplets (LDs), intracellular oil-in-water droplets,
surrounded by a phospholipid and protein monolayer. LDs are at the nexus of cellular lipid …

Cellular cholesterol can be metabolized to its fatty acid esters, cholesteryl esters (CEs), to be
stored in lipid droplets (LDs). With triacylglycerols (TGs), CEs represent the main neutral …