Inhibiting polo-like kinase 1 enhances radiosensitization via modulating DNA repair proteins in non-small-cell lung cancer

D Yao, P Gu, Y Wang, W Luo, H Chi… - Biochemistry and Cell …, 2018 - cdnsciencepub.com
To assure faithful chromosome segregation, cells make use of the spindle assembly
checkpoint, which can be activated in aneuploid cancer cells. In this study, the efficacies of …

[HTML][HTML] PLK1 在恶性肿瘤中的研究进展

郭涛, 王丽娜, 张黎明, 王少强 - Advances in Clinical Medicine, 2023 - hanspub.org
保罗样激酶1 (Polo-like kinase1, PLK1) 属于Polo 样激酶家族, 是一类广泛存在于真核细胞中的
丝氨酸/苏氨酸激酶, 在调节细胞的有丝分裂和DNA 复制中发挥重要作用. 大量研究表明, PLK1 …

BORA regulates cell proliferation and migration in bladder cancer

S Cheng, T Peng, X Zhu, F Zhou, G Wang, L Ju… - Cancer cell …, 2020 - Springer
Background Bladder cancer is having a gradually increasing incidence in China. Except for
the traditional chemotherapy drugs, there are no emerging new drugs for almost 30 years in …

[PDF][PDF] Polo-like Kinase (PLK)

N Sharma, R Vaid, K Dev, A Sourirajan - 2017 - researchgate.net
Different protein kinases govern the progression of cell cycle by the phosphorylation of an
array of their respective substrates. The key cell cycle kinases are polo-like kinase (PLK) …