ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Hydrogen sulfide (H 2 S) and hydrogen polysulfides (H 2 S n) are essential regulatory
signaling molecules generated by the entire body, including the central nervous system …

Neurodegenerative diseases (NDDs) are irreversible, progressive diseases with no effective
treatment. The hallmark of NDDs is the aggregation of misfolded, modified proteins, which …

Protein post-translational modifications (PTMs), which are usually enzymatically catalyzed,
are major regulators of protein activity and involved in almost all celluar processes …

Abstract Peptide arginine deiminase 2 (PAD2) catalyzes the conversion of arginine residues
on target proteins to citrulline residues in the presence of calcium ions. This particular …

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and
Huntington's disease, present challenges in healthcare because of their complicated …

Allergic asthma is characterized by goblet cell metaplasia and subsequent mucus
hypersecretion that contribute to the morbidity and mortality of this disease. Here, we explore …

Perinatal hypoxia-ischemia remains the most common cause of acute neonatal brain injury
and is associated with a high death rate and long-term neurological abnormalities such as …

Posttranslational modifications increase the complexity and functional diversity of proteins in
response to complex external stimuli and internal changes. Among these, protein lipidations …

Recent studies have illustrated the functional significance of DNA recognition in the
activation of innate immune responses among a variety of diseases. The cyclic GMP-AMP …