Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …

The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …

The maintenance of organismal homeostasis requires partitioning and transport of
biochemical molecules between organ systems, their composite cells, and subcellular …

High-throughput technologies have revolutionized medical research. The advent of
genotyping arrays enabled large-scale genome-wide association studies and methods for …

The regulatory loop between long noncoding RNAs (lncRNAs) and microRNAs has a
dynamic role in transcriptional and translational regulation, and is involved in cancer …

Metabolic pathways must be adapted to support cell processes required for transformation
and cancer progression. Amino acid metabolism is deregulated in many cancers, with …

Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

Over the past 20 years, breakthrough discoveries of chromatin-modifying enzymes and
associated mechanisms that alter chromatin in response to physiological or pathological …

BACKGROUND Host immune responses are classically divided into innate immune
responses, which react rapidly and nonspecifically upon encountering a pathogen, and …

Ferroptosis, a novel form of regulated cell death, is different from other types of cell death in
morphology, genetics and biochemistry. Increasing evidence indicates that ferroptosis has …