Transient receptor potential canonical (TRPC) proteins assemble to form homo-or
heterotetrameric, nonselective cation channels permeable to K+, Na+, and Ca2+. TRPC …

Pulmonary arterial hypertension (PAH) is a severe and multifactorial disease. PAH
pathogenesis mostly involves pulmonary arterial endothelial and pulmonary arterial smooth …

Hypoglycemia triggers autonomic and endocrine counter-regulatory responses to restore
glucose homeostasis, a response that is impaired in patients with diabetes and its long-term …

There are many efficient ways to connect proteins at termini. However, connecting at a loop
is difficult because of lower flexibility and variable environment. Here, we have developed …

Abstract TRPC1/4/5 channels are non-specific cation channels implicated in a wide variety
of diseases, and TRPC1/4/5 inhibitors have recently entered clinical trials. However …

Nonsense mutations, which occur in∼ 11% of patients with genetic disorders, introduce
premature termination codons (PTCs) that lead to truncated proteins and promote nonsense …

Photoswitchable reagents can be powerful tools for high‐precision biological control.
TRPC5 is a Ca2+‐permeable cation channel with distinct tissue‐specific roles, from synaptic …

This study investigated the vasorelaxant effects of schwarzinicine A, an alkaloid recently
reported from Ficus schwarzii Koord. Regulation of calcium homeostasis in vascular smooth …

Directly probing the endogenous biological roles of target proteins with high spatial and
temporal resolution, as non-invasively and reproducibly as possible, is a shared conceptual …

Abstract TRPC1/4/5 channels are non-specific cation channels implicated in a wide variety
of diseases, and TRPC1/4/5 inhibitors have recently entered the first clinical trials. However …