Alzheimer's disease (AD), an elderly neurodegenerative disorder with a high incidence and
progressive memory decline, is one of the most expensive, lethal, and burdening diseases …

Insulin‐degrading enzyme (IDE) function goes far beyond its known proteolytic role as a
regulator of insulin levels. IDE has a wide substrate promiscuity, degrading several proteins …

Brain insulin signaling controls peripheral energy metabolism and plays a key role in the
regulation of mood and cognition. Epidemiological studies have indicated a strong …

Since glucose reuptake by neurons is mostly independent of insulin, it has been an
intriguing question whether insulin has or not any roles in the brain. Consequently, the …

The incidence and prevalence of metabolic syndrome has steadily increased worldwide. As
a major risk factor for various diseases, metabolic syndrome has come into focus in recent …

It is well known in clinical practice that Alzheimer's disease (AD) is closely associated with
brain insulin resistance, and the cerebral insulin pathway has been proven to play a critical …

The toxic conformer of amyloid β-protein (Aβ) ending at 42 (Aβ42), which contains a unique
turn conformation at amino acid residue positions 22 and 23 and tends to form oligomers …

As the global population ages, the prevalence of Alzheimer's disease (AD), the most
common form of dementia, is also increasing. At present, there are no widely recognized …

The neurodegenerative Alzheimer's disease (AD) affects more than 30 million people
worldwide. There is thus far no cure or prevention for AD. Aggregation of …

In the field of drug discovery, the large-scale prediction of drug-target affinity (DTA) is
essential. Despite recent advancements in deep learning enhancing DTA prediction, many …