Myeloproliferative neoplasms (MPNs) originate from genetically transformed hematopoietic
stem cells that retain the capacity for multilineage differentiation and effective myelopoiesis …

Juvenile myelomonocytic leukemia (JMML) is a unique, aggressive hematopoietic disorder
of infancy/early childhood caused by excessive proliferation of cells of monocytic and …

Juvenile myelomonocytic leukemia (JMML) is a unique clonal hematopoietic disorder of
early childhood. It is classified as an overlap myeloproliferative/myelodysplastic neoplasm …

Ubiquitination serves as a degradation mechanism of proteins, but is involved in additional
cellular processes such as activation of NFκB inflammatory response and DNA damage …

Juvenile myelomonocytic leukemia (JMML) is an intractable pediatric leukemia with poor
prognosis whose molecular pathogenesis is poorly understood, except for somatic or …

Myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN) are
hematologically diverse stem cell malignancies sharing phenotypic features of both …

RAS signaling plays a key role in controlling appropriate cell responses to extracellular
stimuli and participates in early and late developmental processes. Although enhanced flow …

Single nucleotide polymorphism arrays (SNP-A) have recently been widely applied as a
powerful karyotyping tool in numerous translational cancer studies. SNP-A complements …

RAS genes encode a family of 21 kDa proteins that are an essential hub for a number of
survival, proliferation, differentiation and senescence pathways. Signaling of the RAS …

Myeloid neoplasms derive from the pathological clonal expansion of an abnormal stem cell
and span a diverse spectrum of phenotypes including acute myeloid leukaemia (AML) …