Intratumoral heterogeneity (ITH) has increasingly being described for multiple cancers as
the root cause of therapy resistance. Recent studies have started to explore the scope of ITH …

Amniotic membrane (AM) or amnion is a thin membrane on the inner side of the fetal
placenta; it completely surrounds the embryo and delimits the amniotic cavity, which is filled …

The remarkable developmental potential and replicative capacity of human embryonic stem
(ES) cells promise an almost unlimited supply of specific cell types for transplantation …

Pediatric brain tumors are significant causes of morbidity and mortality. It has been
hypothesized that they derive from self-renewing multipotent neural stem cells. Here, we …

Hearing loss due to damage to auditory hair cells is normally irreversible because
mammalian hair cells do not regenerate. Here, we show that new hair cells can be induced …

The discovery that the adult mammalian brain creates new neurons from pools of stemlike
cells was a breakthrough in neuroscience. Interestingly, this particular new form of structural …

Bromodeoxyuridine (BrdU) is a thymidine analog that incorporates DNA of dividing cells
during the S-phase of the cell cycle. As such, BrdU is used for birth dating and monitoring …

Recent studies demonstrated the neuronogenic role of radial glial cells (RGCs) in the
rodent. To reveal the fate of radial glial processes, we intensively monitored divisions of …

Glia are the most numerous cells in the brain, and their many diverse functions highlight
their essential role in the nervous system. Recent studies have revealed an unexpected new …

Glioblastoma multiforme (GBM) is among the most incurable cancers. GBMs survival rate
has not markedly improved, despite new radical surgery protocols, the introduction of new …