Computational modeling of microbial communities using GEnome-scale Models (GEMs) of
metabolism is a new frontier in systems biology. Here, we discuss recent developments in …

Microbial communities perform emergent activities that are essentially different from those
carried by their individual members. The gut microbiome and its metabolites have a …

Many studies have demonstrated that the gut microbiota is associated with human health
and disease. Manipulation of the gut microbiota, eg supplementation of probiotics, has been …

The human gut is a complex ecosystem consisting of hundreds of microbial species
interacting with each other and with the human host. Mathematical models of the gut …

Construction and analysis of genome-scale metabolic models (GEMs) is a well-established
systems biology approach that can be used to predict metabolic and growth phenotypes …

Metabolic activities of the microbial population are important to maintain the balance of
almost all the ecosystems on earth. In the human gut environment, these microbial …

There are different models available that mimic the human intestinal epithelium and are thus
available for studying probiotic and pathogen interactions in the gastrointestinal tract …

The hybrid cybernetic model (HCM) approach is a dynamic modeling framework that
integrates enzyme synthesis and activity regulation. It has been widely applied in …

Genome-scale metabolic models (GEMs) are valuable tools serving systems biology and
metabolic engineering. However, GEMs are still an underestimated tool in informing …

The rapid development of synthetic biology has significantly improved the capabilities of
mono-culture systems in converting different substrates into various value-added bio …