Mesenchymal stem/stromal cells as a valuable source for the treatment of immune-mediated disorders

A Markov, L Thangavelu, S Aravindhan… - Stem cell research & …, 2021 - Springer
Over recent years, mesenchymal stem/stromal cells (MSCs) and their potential biomedical
applications have received much attention from the global scientific community in an …

Isolation and characterization of extracellular vesicle subpopulations from tissues

R Crescitelli, C Lässer, J Lötvall - Nature protocols, 2021 - nature.com
Extracellular vesicles (EVs) are lipid bilayered membrane structures released by all cells.
Most EV studies have been performed by using cell lines or body fluids, but the number of …

Tetraspanins distinguish separate extracellular vesicle subpopulations in human serum and plasma–Contributions of platelet extracellular vesicles in plasma samples

N Karimi, R Dalirfardouei, T Dias… - Journal of …, 2022 - Wiley Online Library
Background: The ability to isolate extracellular vesicles (EVs) from blood is vital in the
development of EVs as disease biomarkers. Both serum and plasma can be used, but few …

Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin

RE Veerman, L Teeuwen, P Czarnewski… - Journal of …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are increasingly tested as therapeutic vehicles and biomarkers,
but still EV subtypes are not fully characterised. To isolate EVs with few co‐isolated entities …

Role of exosomal non-coding RNAs from tumor cells and tumor-associated macrophages in the tumor microenvironment

Z Xu, Y Chen, L Ma, Y Chen, J Liu, Y Guo, T Yu… - Molecular Therapy, 2022 - cell.com
Exosomes have a crucial role in intercellular communication and mediate interactions
between tumor cells and tumor-associated macrophages (TAMs). Exosome-encapsulated …

RNA-binding proteins contribute to small RNA loading in plant extracellular vesicles

B He, Q Cai, L Qiao, CY Huang, S Wang, W Miao, T Ha… - Nature plants, 2021 - nature.com
Plants use extracellular vesicles (EVs) to transport small RNAs (sRNAs) into their fungal
pathogens and silence fungal virulence-related genes through a phenomenon called 'cross …

Tumor microenvironment: Challenges and opportunities in targeting metastasis of triple negative breast cancer

KGK Deepak, R Vempati, GP Nagaraju… - Pharmacological …, 2020 - Elsevier
Triple negative breast cancer (TNBC) is most aggressive subtype of breast cancers with high
probability of metastasis as well as lack of specific targets and targeted therapeutics. TNBC …

Recent advances of small extracellular vesicle biomarkers in breast cancer diagnosis and prognosis

Y Lee, J Ni, J Beretov, VC Wasinger, P Graham, Y Li - Molecular cancer, 2023 - Springer
Current clinical tools for breast cancer (BC) diagnosis are insufficient but liquid biopsy of
different bodily fluids has recently emerged as a minimally invasive strategy that provides a …

Exosomes and exosome-inspired vesicles for targeted drug delivery

SG Antimisiaris, S Mourtas, A Marazioti - Pharmaceutics, 2018 - mdpi.com
The similarities between exosomes and liposomes, together with the high organotropism of
several types of exosomes, have recently prompted the development of engineered …

[HTML][HTML] Exosome theranostics: biology and translational medicine

C He, S Zheng, Y Luo, B Wang - Theranostics, 2018 - ncbi.nlm.nih.gov
Exosomes are common membrane-bound nanovesicles that contain diverse biomolecules,
such as lipids, proteins, and nucleic acids. Exosomes are derived from cells through …