Past, present, and future perspectives of transcription factor EB (TFEB): mechanisms of regulation and association with disease
Transcription factor EB (TFEB), a member of the MiT/TFE family of basic helix-loop-helix
leucine zipper transcription factors, is an established central regulator of the …
leucine zipper transcription factors, is an established central regulator of the …
Posterior summarization in Bayesian phylogenetics using Tracer 1.7
Cancer is one of the leading causes of death worldwide. There is a definite need for novel
approaches to improve the diagnostics and treatment of cancers. The pathological …
approaches to improve the diagnostics and treatment of cancers. The pathological …
Systematic review of miRNA as biomarkers in Alzheimer's disease
Currently there are 850,000 people with Alzheimer's disease in the UK, with an estimated
rise to 1.1 million by 2025. Alzheimer's disease is characterised by the accumulation of …
rise to 1.1 million by 2025. Alzheimer's disease is characterised by the accumulation of …
The autophagy–lysosomal pathway in neurodegeneration: a TFEB perspective
H Martini-Stoica, Y Xu, A Ballabio, H Zheng - Trends in neurosciences, 2016 - cell.com
The autophagy–lysosomal pathway (ALP) is involved in the degradation of long-lived
proteins. Deficits in the ALP result in protein aggregation, the generation of toxic protein …
proteins. Deficits in the ALP result in protein aggregation, the generation of toxic protein …
Epigenetics of Alzheimer's disease
There are currently no validated biomarkers which can be used to accurately diagnose
Alzheimer's disease (AD) or to distinguish it from other dementia-causing neuropathologies …
Alzheimer's disease (AD) or to distinguish it from other dementia-causing neuropathologies …
Therapeutic potential of vital transcription factors in Alzheimer's and Parkinson's disease with particular emphasis on transcription factor EB mediated autophagy
Autophagy is an important cellular self-digestion and recycling pathway that helps in
maintaining cellular homeostasis. Dysregulation at various steps of the autophagic and …
maintaining cellular homeostasis. Dysregulation at various steps of the autophagic and …
The epigenetics of aging and neurodegeneration
Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …
expression that do not involve changes in the genotype. Epigenetics is of increasing …
A gene network regulating lysosomal biogenesis and function
Lysosomes are organelles central to degradation and recycling processes in animal cells.
Whether lysosomal activity is coordinated to respond to cellular needs remains unclear. We …
Whether lysosomal activity is coordinated to respond to cellular needs remains unclear. We …
microRNAs in Parkinson's disease: from pathogenesis to novel diagnostic and therapeutic approaches
L Leggio, S Vivarelli, F L'Episcopo, C Tirolo… - International journal of …, 2017 - mdpi.com
Parkinson's disease (PD) is the most prevalent central nervous system (CNS) movement
disorder and the second most common neurodegenerative disease overall. PD is …
disorder and the second most common neurodegenerative disease overall. PD is …
MicroRNAs: roles in regulating neuroinflammation
MicroRNAs (miRNAs) are small noncoding RNAs that broadly affect cellular and
physiological function in all multicellular organisms. Here, the role of miRNAs in …
physiological function in all multicellular organisms. Here, the role of miRNAs in …