Past, present, and future perspectives of transcription factor EB (TFEB): mechanisms of regulation and association with disease

A Tan, R Prasad, C Lee, E Jho - Cell Death & Differentiation, 2022 - nature.com
Transcription factor EB (TFEB), a member of the MiT/TFE family of basic helix-loop-helix
leucine zipper transcription factors, is an established central regulator of the …

Posterior summarization in Bayesian phylogenetics using Tracer 1.7

A Rambaut, AJ Drummond, D Xie, G Baele… - Systematic …, 2018 - academic.oup.com
Cancer is one of the leading causes of death worldwide. There is a definite need for novel
approaches to improve the diagnostics and treatment of cancers. The pathological …

Systematic review of miRNA as biomarkers in Alzheimer's disease

S Swarbrick, N Wragg, S Ghosh, A Stolzing - Molecular neurobiology, 2019 - Springer
Currently there are 850,000 people with Alzheimer's disease in the UK, with an estimated
rise to 1.1 million by 2025. Alzheimer's disease is characterised by the accumulation of …

The autophagy–lysosomal pathway in neurodegeneration: a TFEB perspective

H Martini-Stoica, Y Xu, A Ballabio, H Zheng - Trends in neurosciences, 2016 - cell.com
The autophagy–lysosomal pathway (ALP) is involved in the degradation of long-lived
proteins. Deficits in the ALP result in protein aggregation, the generation of toxic protein …

Epigenetics of Alzheimer's disease

M Nikolac Perkovic, A Videtic Paska, M Konjevod… - Biomolecules, 2021 - mdpi.com
There are currently no validated biomarkers which can be used to accurately diagnose
Alzheimer's disease (AD) or to distinguish it from other dementia-causing neuropathologies …

Therapeutic potential of vital transcription factors in Alzheimer's and Parkinson's disease with particular emphasis on transcription factor EB mediated autophagy

SN Rai, N Tiwari, P Singh, D Mishra, AK Singh… - Frontiers in …, 2021 - frontiersin.org
Autophagy is an important cellular self-digestion and recycling pathway that helps in
maintaining cellular homeostasis. Dysregulation at various steps of the autophagic and …

The epigenetics of aging and neurodegeneration

R Lardenoije, A Iatrou, G Kenis, K Kompotis… - Progress in …, 2015 - Elsevier
Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

A gene network regulating lysosomal biogenesis and function

M Sardiello, M Palmieri, A Di Ronza, DL Medina… - Science, 2009 - science.org
Lysosomes are organelles central to degradation and recycling processes in animal cells.
Whether lysosomal activity is coordinated to respond to cellular needs remains unclear. We …

microRNAs in Parkinson's disease: from pathogenesis to novel diagnostic and therapeutic approaches

L Leggio, S Vivarelli, F L'Episcopo, C Tirolo… - International journal of …, 2017 - mdpi.com
Parkinson's disease (PD) is the most prevalent central nervous system (CNS) movement
disorder and the second most common neurodegenerative disease overall. PD is …

MicroRNAs: roles in regulating neuroinflammation

AD Gaudet, LK Fonken, LR Watkins… - The …, 2018 - journals.sagepub.com
MicroRNAs (miRNAs) are small noncoding RNAs that broadly affect cellular and
physiological function in all multicellular organisms. Here, the role of miRNAs in …