[HTML][HTML] Human brain organogenesis: Toward a cellular understanding of development and disease
The construction of the human nervous system is a distinctly complex although highly
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …
[HTML][HTML] Evolution of the human nervous system function, structure, and development
The nervous system—in particular, the brain and its cognitive abilities—is among humans'
most distinctive and impressive attributes. How the nervous system has changed in the …
most distinctive and impressive attributes. How the nervous system has changed in the …
Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex
We used the 10x Genomics Visium platform to define the spatial topography of gene
expression in the six-layered human dorsolateral prefrontal cortex. We identified extensive …
expression in the six-layered human dorsolateral prefrontal cortex. We identified extensive …
Restoration of brain circulation and cellular functions hours post-mortem
Z Vrselja, SG Daniele, J Silbereis, F Talpo… - Nature, 2019 - nature.com
The brains of humans and other mammals are highly vulnerable to interruptions in blood
flow and decreases in oxygen levels. Here we describe the restoration and maintenance of …
flow and decreases in oxygen levels. Here we describe the restoration and maintenance of …
[HTML][HTML] Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
Neurodevelopmental disorders have a heritable component and are associated with region
specific alterations in brain anatomy. However, it is unclear how genetic risks for …
specific alterations in brain anatomy. However, it is unclear how genetic risks for …
[HTML][HTML] Dishing out mini-brains: Current progress and future prospects in brain organoid research
I Kelava, MA Lancaster - Developmental biology, 2016 - Elsevier
The ability to model human brain development in vitro represents an important step in our
study of developmental processes and neurological disorders. Protocols that utilize human …
study of developmental processes and neurological disorders. Protocols that utilize human …
Down syndrome and the complexity of genome dosage imbalance
SE Antonarakis - Nature Reviews Genetics, 2017 - nature.com
Down syndrome (also known as trisomy 21) is the model human phenotype for all genomic
gain dosage imbalances, including microduplications. The functional genomic exploration of …
gain dosage imbalances, including microduplications. The functional genomic exploration of …
GnRH replacement rescues cognition in Down syndrome
M Manfredi-Lozano, V Leysen, M Adamo, I Paiva… - Science, 2022 - science.org
At the present time, no viable treatment exists for cognitive and olfactory deficits in Down
syndrome (DS). We show in a DS model (Ts65Dn mice) that these progressive …
syndrome (DS). We show in a DS model (Ts65Dn mice) that these progressive …
On myelinated axon plasticity and neuronal circuit formation and function
RG Almeida, DA Lyons - Journal of Neuroscience, 2017 - Soc Neuroscience
Studies of activity-driven nervous system plasticity have primarily focused on the gray matter.
However, MRI-based imaging studies have shown that white matter, primarily composed of …
However, MRI-based imaging studies have shown that white matter, primarily composed of …
Altered cell and RNA isoform diversity in aging Down syndrome brains
Down syndrome (DS), trisomy of human chromosome 21 (HSA21), is characterized by
lifelong cognitive impairments and the development of the neuropathological hallmarks of …
lifelong cognitive impairments and the development of the neuropathological hallmarks of …