Contribution of adaptive immunity to human COPD and experimental models of emphysema
F Kheradmand, Y Zhang, DB Corry - Physiological Reviews, 2023 - journals.physiology.org
The pathophysiology of chronic obstructive pulmonary disease (COPD) and the undisputed
role of innate immune cells in this condition have dominated the field in the basic research …
role of innate immune cells in this condition have dominated the field in the basic research …
Machine learning characterization of COPD subtypes: insights from the COPDGene study
COPD is a heterogeneous syndrome. Many COPD subtypes have been proposed, but there
is not yet consensus on how many COPD subtypes there are and how they should be …
is not yet consensus on how many COPD subtypes there are and how they should be …
Emphysema: looking beyond alpha-1 antitrypsin deficiency
R Janssen, I Piscaer, FME Franssen… - Expert review of …, 2019 - Taylor & Francis
Introduction: Distinct pathologies can cause chronic obstructive pulmonary disease (COPD).
Emphysema is a COPD-phenotype characterized by destruction of lung parenchyma. Alpha …
Emphysema is a COPD-phenotype characterized by destruction of lung parenchyma. Alpha …
Update in chronic obstructive pulmonary disease 2019
Chronic obstructive pulmonary disease (COPD) is believed to be associated with both
intrinsic and exogenous disease determinants. The former comprise genetic (1, 2) and …
intrinsic and exogenous disease determinants. The former comprise genetic (1, 2) and …
Identification of an emphysema-associated genetic variant near TGFB2 with regulatory effects in lung fibroblasts
Murine studies have linked TGF-β signaling to emphysema, and human genome-wide
association studies (GWAS) studies of lung function and COPD have identified associated …
association studies (GWAS) studies of lung function and COPD have identified associated …
Relationships of ferroptosis-related genes with the pathogenesis in polycystic ovary syndrome
S Lin, X Jin, H Gu, F Bi - Frontiers in Medicine, 2023 - frontiersin.org
Background Numerous studies have suggested that ferroptosis plays a significant role in the
development of polycystic ovary syndrome (PCOS), but the mechanism remains unclear …
development of polycystic ovary syndrome (PCOS), but the mechanism remains unclear …
Protective effect of club cell secretory protein (CC-16) on COPD risk and progression: a Mendelian randomisation study
Background The anti-inflammatory pneumoprotein club cell secretory protein-16 (CC-16) is
associated with the clinical expression of chronic obstructive pulmonary disease (COPD) …
associated with the clinical expression of chronic obstructive pulmonary disease (COPD) …
Lung Transcriptomics Link Emphysema to Barrier Dysfunction and Macrophage Subpopulations
R Lu, A Gregory, R Suryadevara, Z Xu… - American Journal of …, 2025 - atsjournals.org
Rationale: Although many studies have examined gene expression in lung tissue, the gene
regulatory processes underlying emphysema are still not well understood. Finding efficient …
regulatory processes underlying emphysema are still not well understood. Finding efficient …
Characterization of a COPD-Associated NPNT Functional Splicing Genetic Variant in Human Lung Tissue via Long-Read Sequencing
Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide.
Genome-wide association studies (GWAS) have identified over 80 loci that are associated …
Genome-wide association studies (GWAS) have identified over 80 loci that are associated …
Quantifying the spatial clustering characteristics of radiographic emphysema explains variability in pulmonary function
Quantitative assessment of emphysema in CT scans has mostly focused on calculating the
percentage of lung tissue that is deemed abnormal based on a density thresholding …
percentage of lung tissue that is deemed abnormal based on a density thresholding …