Obesity, adipose tissue and vascular dysfunction

M Koenen, MA Hill, P Cohen, JR Sowers - Circulation research, 2021 - Am Heart Assoc
Cardiovascular diseases are the leading cause of death worldwide. Overweight and obesity
are strongly associated with comorbidities such as hypertension and insulin resistance …

Obesity-induced changes in adipose tissue microenvironment and their impact on cardiovascular disease

JJ Fuster, N Ouchi, N Gokce, K Walsh - Circulation research, 2016 - Am Heart Assoc
Obesity is causally linked with the development of cardiovascular disorders. Accumulating
evidence indicates that cardiovascular disease is the collateral damage of obesity-driven …

Protective effects of curcumin in cardiovascular diseases—Impact on oxidative stress and mitochondria

FF Cox, A Misiou, A Vierkant, N Ale-Agha, M Grandoch… - Cells, 2022 - mdpi.com
Cardiovascular diseases (CVDs) contribute to a large part of worldwide mortality. Similarly,
two of the major risk factors for these diseases, aging and obesity, are also global problems …

Inflammation of brown/beige adipose tissues in obesity and metabolic disease

F Villarroya, R Cereijo… - Journal of internal …, 2018 - Wiley Online Library
Many of the comorbidities of obesity, including type 2 diabetes and cardiovascular diseases,
are related to the low‐grade chronic inflammation of white adipose tissue. Under white …

Mechanistic links between obesity, diabetes, and blood pressure: role of perivascular adipose tissue

SN Saxton, BJ Clark, SB Withers… - Physiological …, 2019 - journals.physiology.org
Obesity is increasingly prevalent and is associated with substantial cardiovascular risk.
Adipose tissue distribution and morphology play a key role in determining the degree of …

Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials

E Marzetti, R Calvani, M Cesari, TW Buford… - The international journal …, 2013 - Elsevier
Sarcopenia, the age-related loss of muscle mass and function, imposes a dramatic burden
on individuals and society. The development of preventive and therapeutic strategies …

Epicardial and perivascular adipose tissues and their influence on cardiovascular disease: basic mechanisms and clinical associations

TP Fitzgibbons, MP Czech - Journal of the American Heart …, 2014 - Am Heart Assoc
It is well established that the cardiovascular (CV) risk of obesity is more strongly associated
with visceral rather than subcutaneous adiposity. 1–3 Anthropometric variables that account …

Obesity phenotypes and cardiovascular risk: from pathophysiology to clinical management

A Preda, F Carbone, A Tirandi, F Montecucco… - Reviews in Endocrine …, 2023 - Springer
Obesity epidemic reached the dimensions of a real global health crisis with more than one
billion people worldwide living with obesity. Multiple obesity-related mechanisms cause …

The role of perivascular adipose tissue in obesity‐induced vascular dysfunction

N Xia, H Li - British journal of pharmacology, 2017 - Wiley Online Library
Under physiological conditions, perivascular adipose tissue (PVAT) attenuates agonist‐
induced vasoconstriction by releasing vasoactive molecules including hydrogen peroxide …

Perivascular adipose tissue (PVAT) in atherosclerosis: a double-edged sword

XY Qi, SL Qu, WH Xiong, O Rom, L Chang… - Cardiovascular …, 2018 - Springer
Perivascular adipose tissue (PVAT), the adipose tissue that surrounds most of the
vasculature, has emerged as an active component of the blood vessel wall regulating …