Abstract Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …

Protein phosphatase type 2A (PP2A) enzymes constitute a large family of Ser/Thr
phosphatases with multiple functions in cellular signaling and physiology. The composition …

Ataxia telangiectasia mutated (ATM) plays a critical role in the cellular response to DNA
damage. In response to DNA double-strand breaks (DSBs), ATM is autophosphorylated at …

Protein phosphatases of the type 2A family (PP2A) represent a major fraction of cellular
Ser/Thr phosphatase activity in any given human tissue. In this review, we describe how the …

PP2A is a highly conserved eukaryotic serine/threonine protein phosphatase of the PPP
family of phosphatases with fundamental cellular functions. In cells, PP2A targets specific …

Abstract Protein phosphatase 2A (PP2A) holoenzymes target broad substrates by
recognizing short motifs via regulatory subunits. PP2A methylesterase 1 (PME-1) is a cancer …

The antagonistic actions of Polycomb and Trithorax are responsible for proper cell fate
determination in mammalian tissues. In the epidermis, a self-renewing epithelium, previous …

The B ″/PR72 family of protein phosphatase 2A (PP2A) is an important PP2A family
involved in diverse cellular processes, and uniquely regulated by calcium binding to the …

Cellular processes are dictated by the active signaling of proteins relaying messages to
regulate cell proliferation, apoptosis, signal transduction and cell communications. An …

Abstract Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase. This
enzyme is involved in a plethora of cellular processes, including apoptosis, autophagy, cell …