Reelin functions, mechanisms of action and signaling pathways during brain development and maturation
Y Jossin - Biomolecules, 2020 - mdpi.com
During embryonic development and adulthood, Reelin exerts several important functions in
the brain including the regulation of neuronal migration, dendritic growth and branching …
the brain including the regulation of neuronal migration, dendritic growth and branching …
Shaping synapses by the neural extracellular matrix
M Ferrer-Ferrer, A Dityatev - Frontiers in neuroanatomy, 2018 - frontiersin.org
Accumulating data support the importance of interactions between pre-and postsynaptic
neuronal elements with astroglial processes and extracellular matrix (ECM) for formation …
neuronal elements with astroglial processes and extracellular matrix (ECM) for formation …
Lymphoangiocrine signals promote cardiac growth and repair
Recent studies have suggested that lymphatics help to restore heart function after cardiac
injury,,,,–. Here we report that lymphatics promote cardiac growth, repair and …
injury,,,,–. Here we report that lymphatics promote cardiac growth, repair and …
Reelin and neuropsychiatric disorders
Proper neuronal migration and laminar formation during corticogenesis is essential for
normal brain function. Disruption of these developmental processes is thought to be …
normal brain function. Disruption of these developmental processes is thought to be …
New insights into reelin-mediated signaling pathways
GH Lee, G D'Arcangelo - Frontiers in cellular neuroscience, 2016 - frontiersin.org
Reelin, a multifunctional extracellular protein that is important for mammalian brain
development and function, is secreted by different cell types in the prenatal or postnatal …
development and function, is secreted by different cell types in the prenatal or postnatal …
ApoE, ApoE receptors, and the synapse in Alzheimer's disease
C Lane-Donovan, J Herz - Trends in Endocrinology & Metabolism, 2017 - cell.com
As the population ages, neurodegenerative diseases such as Alzheimer's disease (AD) are
becoming a significant burden on patients, their families, and health-care systems …
becoming a significant burden on patients, their families, and health-care systems …
Regulation of the hippocampal translatome by Apoer2-ICD release
CR Wasser, GC Werthmann, EM Hall… - Molecular …, 2023 - Springer
Background ApoE4, the most significant genetic risk factor for late-onset Alzheimer's disease
(AD), sequesters a pro-synaptogenic Reelin receptor, Apoer2, in the endosomal …
(AD), sequesters a pro-synaptogenic Reelin receptor, Apoer2, in the endosomal …
Reelin: neurodevelopmental architect and homeostatic regulator of excitatory synapses
CR Wasser, J Herz - Journal of Biological Chemistry, 2017 - ASBMB
Over half a century ago, DS Falconer first reported a mouse with a reeling gate. Four
decades later, the Reln gene was isolated and identified as the cause of the reeler …
decades later, the Reln gene was isolated and identified as the cause of the reeler …
Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides
AJ Hinrich, FM Jodelka, JL Chang… - EMBO molecular …, 2016 - embopress.org
Abstract Apolipoprotein E receptor 2 (Apo ER 2) is an apolipoprotein E receptor involved in
long‐term potentiation, learning, and memory. Given its role in cognition and its association …
long‐term potentiation, learning, and memory. Given its role in cognition and its association …
Canonical and non-canonical reelin signaling
HH Bock, P May - Frontiers in cellular neuroscience, 2016 - frontiersin.org
Reelin is a large secreted glycoprotein that is essential for correct neuronal positioning
during neurodevelopment and is important for synaptic plasticity in the mature brain …
during neurodevelopment and is important for synaptic plasticity in the mature brain …