Reelin functions, mechanisms of action and signaling pathways during brain development and maturation

Y Jossin - Biomolecules, 2020 - mdpi.com
During embryonic development and adulthood, Reelin exerts several important functions in
the brain including the regulation of neuronal migration, dendritic growth and branching …

Shaping synapses by the neural extracellular matrix

M Ferrer-Ferrer, A Dityatev - Frontiers in neuroanatomy, 2018 - frontiersin.org
Accumulating data support the importance of interactions between pre-and postsynaptic
neuronal elements with astroglial processes and extracellular matrix (ECM) for formation …

Lymphoangiocrine signals promote cardiac growth and repair

X Liu, E De la Cruz, X Gu, L Balint, M Oxendine-Burns… - Nature, 2020 - nature.com
Recent studies have suggested that lymphatics help to restore heart function after cardiac
injury,,,,–. Here we report that lymphatics promote cardiac growth, repair and …

Reelin and neuropsychiatric disorders

K Ishii, K Kubo, K Nakajima - Frontiers in cellular neuroscience, 2016 - frontiersin.org
Proper neuronal migration and laminar formation during corticogenesis is essential for
normal brain function. Disruption of these developmental processes is thought to be …

New insights into reelin-mediated signaling pathways

GH Lee, G D'Arcangelo - Frontiers in cellular neuroscience, 2016 - frontiersin.org
Reelin, a multifunctional extracellular protein that is important for mammalian brain
development and function, is secreted by different cell types in the prenatal or postnatal …

ApoE, ApoE receptors, and the synapse in Alzheimer's disease

C Lane-Donovan, J Herz - Trends in Endocrinology & Metabolism, 2017 - cell.com
As the population ages, neurodegenerative diseases such as Alzheimer's disease (AD) are
becoming a significant burden on patients, their families, and health-care systems …

Regulation of the hippocampal translatome by Apoer2-ICD release

CR Wasser, GC Werthmann, EM Hall… - Molecular …, 2023 - Springer
Background ApoE4, the most significant genetic risk factor for late-onset Alzheimer's disease
(AD), sequesters a pro-synaptogenic Reelin receptor, Apoer2, in the endosomal …

Reelin: neurodevelopmental architect and homeostatic regulator of excitatory synapses

CR Wasser, J Herz - Journal of Biological Chemistry, 2017 - ASBMB
Over half a century ago, DS Falconer first reported a mouse with a reeling gate. Four
decades later, the Reln gene was isolated and identified as the cause of the reeler …

Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides

AJ Hinrich, FM Jodelka, JL Chang… - EMBO molecular …, 2016 - embopress.org
Abstract Apolipoprotein E receptor 2 (Apo ER 2) is an apolipoprotein E receptor involved in
long‐term potentiation, learning, and memory. Given its role in cognition and its association …

Canonical and non-canonical reelin signaling

HH Bock, P May - Frontiers in cellular neuroscience, 2016 - frontiersin.org
Reelin is a large secreted glycoprotein that is essential for correct neuronal positioning
during neurodevelopment and is important for synaptic plasticity in the mature brain …