The role of microbiome in brain development and neurodegenerative diseases

V Nandwana, NK Nandwana, Y Das, M Saito, T Panda… - Molecules, 2022 - mdpi.com
Hundreds of billions of commensal microorganisms live in and on our bodies, most of which
colonize the gut shortly after birth and stay there for the rest of our lives. In animal models …

Boron-containing compounds on neurons: Actions and potential applications for treating neurodegenerative diseases

M Barrón-González, AV Montes-Aparicio… - Journal of Inorganic …, 2023 - Elsevier
Boron-containing compounds (BCC) exert effects on neurons. After the expanding of both
the identification and synthesis of new BCC, novel effects in living systems have been …

COEXPEDIA: exploring biomedical hypotheses via co-expressions associated with medical subject headings (MeSH)

S Yang, CY Kim, S Hwang, E Kim, H Kim… - Nucleic acids …, 2017 - academic.oup.com
The use of high-throughput array and sequencing technologies has produced
unprecedented amounts of gene expression data in central public depositories, including …

Role of nanomedicine-based therapeutics in the treatment of CNS disorders

ZH Guo, S Khattak, MA Rauf, MA Ansari, MN Alomary… - Molecules, 2023 - mdpi.com
Central nervous system disorders, especially neurodegenerative diseases, are a public
health priority and demand a strong scientific response. Various therapy procedures have …

Synthesis, in silico, and biological evaluation of a borinic tryptophan-derivative that induces melatonin-like amelioration of cognitive deficit in male rat

M Barrón-González, MC Rosales-Hernández… - International Journal of …, 2022 - mdpi.com
Preclinical and clinical evidence supports melatonin and its analogues as potential
treatment for diseases involving cognitive deficit such as Alzheimer's disease. In this work …

Boronic acid-based enzyme inhibitors: a review of recent progress

H Fu, H Fang, J Sun, H Wang, A Liu… - Current Medicinal …, 2014 - ingentaconnect.com
Since Bortezomib was approved by US FDA as the first drug to treat multiple myeloma,
various boronic acid compounds have been developed as enzyme inhibitors. This paper …

Boronic Acids and Beyond: ROS-responsive prodrugs as tools for a safer and more effective cancer chemotherapy

SAG Monteiro, PMP Gois, JPM António - Synlett, 2023 - thieme-connect.com
Despite significant scientific advances and the wide variety of available treatments, cancer
remains a major cause of death worldwide. Chemotherapy, which is frequently one of the …

Ruthenium‐Catalyzed One‐Pot Synthesis of (E)‐(2‐Arylvinyl)boronates through an Isomerization/Cross‐Metathesis Sequence from Allyl‐Substituted Aromatics

R Hemelaere, F Caijo, M Mauduit… - European Journal of …, 2014 - Wiley Online Library
We described the efficient preparation of (E)‐(2‐arylvinyl) boronates from allylbenzene
derivatives on the basis of an isomerization/cross‐metathesis sequence catalyzed by a …

The Cracked Potential of Boron-containing Compounds in Alzheimer's Disease

MA Soriano-Ursúa… - Central Nervous System …, 2023 - ingentaconnect.com
Alzheimer's disease (AD) is a relevant neurodegenerative disease worldwide. Its relevancy
is mainly due to its high prevalence and high global burden. Metalloids have attracted …

Discovery of boronic acid-based fluorescent probes targeting amyloid-beta plaques in Alzheimer's disease

SJ Jung, JY Lee, TH Kim, DE Lee, J Jeon… - Bioorganic & Medicinal …, 2016 - Elsevier
A boronic acid-based fluorescent probe was developed for diagnosis of amyloid-β (Aβ)
plaques from Alzheimer's disease (AD). Probe 4c, which included boronic acid as a …