Axons are considered to be particularly vulnerable components of the nervous system;
impairments to a neuron's axon leads to an effective silencing of a neuron's ability to …

The c-Jun NH2-terminal protein kinase (JNK) is a Janus-faced kinase, which, in the nervous
system, plays important roles in a broad range of physiological and pathological processes …

Axonal degeneration is a common pathological feature in many acute and chronic
neurological diseases such as spinal cord injury (SCI). SARM1 (sterile alpha and TIR motif …

Introduction The degeneration of injured axons is driven by conserved molecules, including
the sterile armadillo TIR domain-containing protein SARM1, the cJun N-terminal kinase JNK …

Following acute neural injury, severed axons undergo programmed Wallerian degeneration
over several following days. While sleep has been linked with synaptic reorganization under …

ABSTRACT HTT (huntingtin) is a 350-kDa protein of unknown function. While HTT moves
bidirectionally within axons and HTT loss/reduction causes axonal transport defects, the …

Dendrites are cellular structures essential for the integration of neuronal information. These
elegant but complex structures are highly patterned across the nervous system but vary …

The long length of axons makes them vulnerable to damage; hence, it is logical that nervous
systems have evolved adaptive mechanisms for responding to axon damage. Studies in …

Reactive oxygen species (ROS) are generated during physiological bouts of synaptic activity
and as a consequence of pathological conditions in the central nervous system. How …

The degeneration of axons and their terminals occurs following traumatic, toxic, or
genetically-induced insults. Common molecular mechanisms unite these disparate triggers …