This chapter gives an overview of methods for the synthesis of NH-and N (2)-substituted 1, 2,
3-triazoles, their advantages, lacks, scope, and limitations. Moreover, it will give some …

Privileged structures have been widely used as effective templates for drug discovery. While
benzo‐1, 4‐diazepine constitutes the first historical example of such a structure, the 1, 3 …

Recent focus on ureas stems from their wide range of application in petrochemicals,
agrochemicals, and pharmaceuticals.'Used as dyes for cellulose fibres, antioxidants in …

In this report, a visible-light-driven photocyclization reaction of aryl azides to access 2H-
indazole-3-carboxamides in moderate to excellent yields has been realized efficiently under …

We have previously reported on the unexpected flipped conformation in the cyclic sulfamide
class of inhibitors. An attempt to induce a symmetric binding conformation by introducing …

Two types of adenosine receptor ligands were designed, ie, 9 H-purine and 1 H-imidazo [4,
5-c] pyridines, to obtain selective A2A antagonists, and we report here their synthesis and …

A series of simple heterocyclic HIV-1 protease inhibitors were developed on the basis of
size, shape, and electronic complementarity to the active site of the enzyme. The C 2 …

UNSYMMETRICAL CYCLIC UREAS AS HIV-1 PROTEASE INHIBITORS: NOVEL BIARYL
INDAZOLES AS P2/P2' SUBSTITUENTS " -' " "- Page 1 BIOORGANIC & "~ MEDICINAL …

Purpose. To optimize the conditions for determining Caco-2 permeation of HIV protease
inhibitors and other lipophilic compounds, and to compare cyclic urea HIV protease …

The review systematizes and summarizes data on the synthesis of structurally diverse cyclic
ureas published over the last 10 years. Saturated and unsaturated monocyclic ureas, as well …