The glycine receptor chloride channel (GlyR) is a member of the nicotinic acetylcholine
receptor family of ligand-gated ion channels. Functional receptors of this family comprise five …

Cys-loop receptors are membrane-spanning neurotransmitter-gated ion channels that are
responsible for fast excitatory and inhibitory transmission in the peripheral and central …

The nicotinic acetylcholine receptor (AChR) is the archetype molecule in the superfamily of
ligand-gated ion channels (LGIC). Members of this superfamily mediate fast intercellular …

Nicotine, a component of tobacco, is highly addictive but possesses beneficial properties
such as cognitive improvements and memory maintenance. Involved in these processes is …

The inhibitory glycine receptor (GlyR) 1 is a member of the nicotinicoid receptor superfamily
that includes the inhibitory-aminobutyric acid, type A, receptor (GABAAR) and the excitatory …

Using the crosstalk between the nicotinic acetylcholine receptor (nAChR) and its lipid
microenvironment as a paradigm, this short overview analyzes the occurrence of structural …

The photoaffinity labeling of amino acid residues embedded in the lipid bilayer, in
combination with site-directed mutagenesis and patch-clamp electrophysiology, are …

Pentameric ligand-gated ion channels (pLGICs) and their lipid microenvironments appear to
have acquired mutually adaptive traits along evolution: 1) the three-ring architecture of their …

The functional role of the αM3 transmembrane domain of the Torpedo nicotinic acetylcholine
receptor (AChR) was characterized by performing tryptophan-scanning mutagenesis at 13 …

A recent tryptophan scanning of the α-TM3 domain of the Torpedo californica AChR
demonstrated that this domain can modulate ion-channel gating [Guzman, G., Santiago, J …