Molecular structure and function of the glycine receptor chloride channel
JW Lynch - Physiological reviews, 2004 - journals.physiology.org
The glycine receptor chloride channel (GlyR) is a member of the nicotinic acetylcholine
receptor family of ligand-gated ion channels. Functional receptors of this family comprise five …
receptor family of ligand-gated ion channels. Functional receptors of this family comprise five …
The structural basis of function in Cys-loop receptors
AJ Thompson, HA Lester… - Quarterly reviews of …, 2010 - cambridge.org
Cys-loop receptors are membrane-spanning neurotransmitter-gated ion channels that are
responsible for fast excitatory and inhibitory transmission in the peripheral and central …
responsible for fast excitatory and inhibitory transmission in the peripheral and central …
Structural basis for lipid modulation of nicotinic acetylcholine receptor function
FJ Barrantes - Brain Research Reviews, 2004 - Elsevier
The nicotinic acetylcholine receptor (AChR) is the archetype molecule in the superfamily of
ligand-gated ion channels (LGIC). Members of this superfamily mediate fast intercellular …
ligand-gated ion channels (LGIC). Members of this superfamily mediate fast intercellular …
α7 neuronal nicotinic acetylcholine receptors are negatively regulated by tyrosine phosphorylation and Src-family kinases
E Charpantier, A Wiesner, KH Huh, R Ogier… - Journal of …, 2005 - Soc Neuroscience
Nicotine, a component of tobacco, is highly addictive but possesses beneficial properties
such as cognitive improvements and memory maintenance. Involved in these processes is …
such as cognitive improvements and memory maintenance. Involved in these processes is …
[HTML][HTML] Structure and function of the glycine receptor and related nicotinicoid receptors
M Cascio - Journal of Biological Chemistry, 2004 - ASBMB
The inhibitory glycine receptor (GlyR) 1 is a member of the nicotinicoid receptor superfamily
that includes the inhibitory-aminobutyric acid, type A, receptor (GABAAR) and the excitatory …
that includes the inhibitory-aminobutyric acid, type A, receptor (GABAAR) and the excitatory …
[HTML][HTML] Phylogenetic conservation of protein–lipid motifs in pentameric ligand-gated ion channels
FJ Barrantes - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2015 - Elsevier
Using the crosstalk between the nicotinic acetylcholine receptor (nAChR) and its lipid
microenvironment as a paradigm, this short overview analyzes the occurrence of structural …
microenvironment as a paradigm, this short overview analyzes the occurrence of structural …
[PDF][PDF] Modulation of nicotinic acetylcholine receptor function through the outer and middle rings of transmembrane domains
FJ Barrantes - Current Opinion in Drug Discovery and …, 2003 - researchgate.net
The photoaffinity labeling of amino acid residues embedded in the lipid bilayer, in
combination with site-directed mutagenesis and patch-clamp electrophysiology, are …
combination with site-directed mutagenesis and patch-clamp electrophysiology, are …
From hopanoids to cholesterol: Molecular clocks of pentameric ligand-gated ion channels
FJ Barrantes, J Fantini - Progress in lipid research, 2016 - Elsevier
Pentameric ligand-gated ion channels (pLGICs) and their lipid microenvironments appear to
have acquired mutually adaptive traits along evolution: 1) the three-ring architecture of their …
have acquired mutually adaptive traits along evolution: 1) the three-ring architecture of their …
Tryptophan Scanning Mutagenesis in the αM3 Transmembrane Domain of the Torpedo californica Acetylcholine Receptor: Functional and Structural Implications
GR Guzmán, J Santiago, A Ricardo, R Martí-Arbona… - Biochemistry, 2003 - ACS Publications
The functional role of the αM3 transmembrane domain of the Torpedo nicotinic acetylcholine
receptor (AChR) was characterized by performing tryptophan-scanning mutagenesis at 13 …
receptor (AChR) was characterized by performing tryptophan-scanning mutagenesis at 13 …
Tryptophan Substitutions Reveal the Role of Nicotinic Acetylcholine Receptor α-TM3 Domain in Channel Gating: Differences between Torpedo and Muscle-Type …
A recent tryptophan scanning of the α-TM3 domain of the Torpedo californica AChR
demonstrated that this domain can modulate ion-channel gating [Guzman, G., Santiago, J …
demonstrated that this domain can modulate ion-channel gating [Guzman, G., Santiago, J …