COVID-19: a global challenge with old history, epidemiology and progress so far

M Khan, SF Adil, HZ Alkhathlan, MN Tahir, S Saif… - Molecules, 2020 - mdpi.com
Humans have witnessed three deadly pandemics so far in the twenty-first century which are
associated with novel coronaviruses: SARS, Middle East respiratory syndrome (MERS), and …

Ecology, evolution and spillover of coronaviruses from bats

M Ruiz-Aravena, C McKee, A Gamble, T Lunn… - Nature Reviews …, 2022 - nature.com
In the past two decades, three coronaviruses with ancestral origins in bats have emerged
and caused widespread outbreaks in humans, including severe acute respiratory syndrome …

[HTML][HTML] Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses

H Zhou, J Ji, X Chen, Y Bi, J Li, Q Wang, T Hu, H Song… - Cell, 2021 - cell.com
Despite the discovery of animal coronaviruses related to SARS-CoV-2, the evolutionary
origins of this virus are elusive. We describe a meta-transcriptomic study of 411 bat samples …

COVID-19: Immunology and treatment options

S Felsenstein, JA Herbert, PS McNamara… - Clinical …, 2020 - Elsevier
The novel coronavirus SARS-CoV2 causes COVID-19, a pandemic threatening millions. As
protective immunity does not exist in humans and the virus is capable of escaping innate …

Candidate drugs against SARS-CoV-2 and COVID-19

DL McKee, A Sternberg, U Stange, S Laufer… - Pharmacological …, 2020 - Elsevier
Outbreak and pandemic of coronavirus SARS-CoV-2 in 2019/2020 will challenge global
health for the future. Because a vaccine against the virus will not be available in the near …

Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates

J Damas, GM Hughes, KC Keough… - Proceedings of the …, 2020 - National Acad Sciences
The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
the cause of COVID-19. The main receptor of SARS-CoV-2, angiotensin I converting enzyme …

Research and development on therapeutic agents and vaccines for COVID-19 and related human coronavirus diseases

C Liu, Q Zhou, Y Li, LV Garner, SP Watkins, LJ Carter… - 2020 - ACS Publications
Since the outbreak of the novel coronavirus disease COVID-19, caused by the SARS-CoV-2
virus, this disease has spread rapidly around the globe. Considering the potential threat of a …

[HTML][HTML] Universal coronavirus vaccines—an urgent need

DM Morens, JK Taubenberger… - New England Journal of …, 2022 - Mass Medical Soc
Universal Coronavirus Vaccines—An Urgent Need We need a research approach that can
characterize the global coronaviral universe, characterize the natural history and …

[HTML][HTML] Origin and evolution of pathogenic coronaviruses

J Cui, F Li, ZL Shi - Nature reviews microbiology, 2019 - nature.com
Severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory
syndrome coronavirus (MERS-CoV) are two highly transmissible and pathogenic viruses …

Bat-borne virus diversity, spillover and emergence

M Letko, SN Seifert, KJ Olival, RK Plowright… - Nature Reviews …, 2020 - nature.com
Most viral pathogens in humans have animal origins and arose through cross-species
transmission. Over the past 50 years, several viruses, including Ebola virus, Marburg virus …