Macrophages are integral components of cardiac tissue and exert profound effects on the
healthy and diseased heart. Paradigm shifting studies using advanced molecular …

Anticancer drugs continue to cause significant reductions in left ventricular ejection fraction
resulting in congestive heart failure. The best-known cardiotoxic agents are anthracyclines …

Anthracyclines, such as doxorubicin, are the most potent and widely used chemotherapeutic
agents for the treatment of a variety of human cancers, including solid tumors and …

Aims Combined administration of anthracyclines (eg doxorubicin; Dox) and trastuzumab
(Trz), a humanized anti-human epidermal growth factor receptor 2 (HER2; ErbB2), is an …

Medical systems worldwide are being faced with a growing need to understand mechanisms
behind the pathogenesis of heart failure (HF) that is considered as a leading cause of …

Doxorubicin is one of the most effective chemotherapeutic agents used for cancer treatment,
but it causes systemic inflammation and serious multiorgan side effects in many patients. In …

Activation of the immune system in heart failure (HF) has been recognized for over 20 years.
Initially, experimental studies demonstrated a maladaptive role of the immune system …

Antineoplastic drugs can be associated with several side effects, including cardiovascular
toxicity (CTX). Biochemical studies have identified multiple mechanisms of CTX …

Cancer remains a major public health problem worldwide and was responsible for 9.6
million deaths in 2018. Oncologic treatments such as doxorubicin (Dox) and trastuzumab …

Innate immune cells are the early responders to infection and tissue damage. They play a
critical role in the initiation and resolution of inflammation in response to insult as well as …