Ageing and rejuvenation of tissue stem cells and their niches
Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …
Control of satellite cell function in muscle regeneration and its disruption in ageing
P Sousa-Victor, L García-Prat… - … Reviews Molecular Cell …, 2022 - nature.com
Skeletal muscle contains a designated population of adult stem cells, called satellite cells,
which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically …
which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically …
[HTML][HTML] Perspectives on skeletal muscle stem cells
F Relaix, M Bencze, MJ Borok, A Der Vartanian… - Nature …, 2021 - nature.com
Skeletal muscle has remarkable regeneration capabilities, mainly due to its resident muscle
stem cells (MuSCs). In this review, we introduce recently developed technologies and the …
stem cells (MuSCs). In this review, we introduce recently developed technologies and the …
[HTML][HTML] Single-cell analysis of the muscle stem cell hierarchy identifies heterotypic communication signals involved in skeletal muscle regeneration
AJ De Micheli, EJ Laurilliard, CL Heinke… - Cell reports, 2020 - cell.com
Muscle regeneration relies on the regulation of muscle stem cells (MuSCs) through
paracrine signaling interactions. We analyzed muscle regeneration in mice using single-cell …
paracrine signaling interactions. We analyzed muscle regeneration in mice using single-cell …
The meaning of adaptation in aging: insights from cellular senescence, epigenetic clocks and stem cell alterations
M Ogrodnik, VN Gladyshev - Nature Aging, 2023 - nature.com
With recent rapid progress in research on aging, there is increasing evidence that many
features commonly considered to be mechanisms or drivers of aging in fact represent …
features commonly considered to be mechanisms or drivers of aging in fact represent …
[HTML][HTML] Adult stem cells at work: regenerating skeletal muscle
Skeletal muscle regeneration is a finely tuned process involving the activation of various
cellular and molecular processes. Satellite cells, the stem cells of skeletal muscle, are …
cellular and molecular processes. Satellite cells, the stem cells of skeletal muscle, are …
FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age
L García-Prat, E Perdiguero, S Alonso-Martin… - Nature cell …, 2020 - nature.com
Tissue regeneration declines with ageing but little is known about whether this arises from
changes in stem-cell heterogeneity. Here, in homeostatic skeletal muscle, we identify two …
changes in stem-cell heterogeneity. Here, in homeostatic skeletal muscle, we identify two …
[HTML][HTML] Aging disrupts muscle stem cell function by impairing matricellular WISP1 secretion from fibro-adipogenic progenitors
L Lukjanenko, S Karaz, P Stuelsatz… - Cell stem cell, 2019 - cell.com
Research on age-related regenerative failure of skeletal muscle has extensively focused on
the phenotypes of muscle stem cells (MuSCs). In contrast, the impact of aging on regulatory …
the phenotypes of muscle stem cells (MuSCs). In contrast, the impact of aging on regulatory …
[HTML][HTML] Orienting muscle stem cells for regeneration in homeostasis, aging, and disease
P Feige, CE Brun, M Ritso, MA Rudnicki - Cell stem cell, 2018 - cell.com
Muscle stem cells, or satellite cells, are required for skeletal muscle maintenance, growth,
and repair. Following satellite cell activation, several factors drive asymmetric cell division to …
and repair. Following satellite cell activation, several factors drive asymmetric cell division to …
[HTML][HTML] Multiomics reveals glutathione metabolism as a driver of bimodality during stem cell aging
DI Benjamin, JO Brett, P Both, JS Benjamin, HL Ishak… - Cell metabolism, 2023 - cell.com
With age, skeletal muscle stem cells (MuSCs) activate out of quiescence more slowly and
with increased death, leading to defective muscle repair. To explore the molecular …
with increased death, leading to defective muscle repair. To explore the molecular …