Amyloid-beta (Aß) and hyperphosphorylated tau are hallmark lesions of Alzheimer's disease
(AD). However, the loss of synapses and dysfunctions of neurotransmission are more …

One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-
activated protein kinase (AMPK), which is activated when intracellular ATP production …

The common fruit fly, Drosophila melanogaster, is a well studied and highly tractable genetic
model organism for understanding molecular mechanisms of human diseases. Many basic …

Calcium (Ca2+) homeostasis is essential for neuronal function and survival. Altered Ca2+
homeostasis has been consistently observed in neurological diseases. How Ca2+ …

Recent evidence suggests that glycogen synthase kinase 3 (GSK3) proteins and their
upstream and downstream regulators have key roles in many fundamental processes during …

Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved
serine/threonine protein kinase encoded in mammals by two genes that generate two …

Tau is a microtubule-associated-protein that is sorted into neuronal axons in physiological
conditions. In Alzheimer disease (AD) and other tauopathies, Tau sorting mechanisms fail …

Summary Amyloid-β 1–42 (Aβ42) oligomers are synaptotoxic for excitatory cortical and
hippocampal neurons and might play a role in early stages of Alzheimer's disease (AD) …

Mitochondrial abnormalities have been documented in Alzheimer's disease and related
neurodegenerative disorders, but the causal relationship between mitochondrial changes …

Tau is a group of neuronal microtubule-associated proteins that are formed by alternative
mRNA splicing and accumulate in neurofibrillary tangles in Alzheimer's disease (AD) brain …