Microbiota-mediated colonization resistance: mechanisms and regulation

G Caballero-Flores, JM Pickard, G Núñez - Nature Reviews …, 2023 - nature.com
A dense and diverse microbial community inhabits the gut and many epithelial surfaces.
Referred to as the microbiota, it co-evolved with the host and is beneficial for many host …

Gut microbiota and colonization resistance against bacterial enteric infection

QR Ducarmon, RD Zwittink, BVH Hornung… - Microbiology and …, 2019 - Am Soc Microbiol
The gut microbiome is critical in providing resistance against colonization by exogenous
microorganisms. The mechanisms via which the gut microbiota provide colonization …

[HTML][HTML] Dysbiosis-induced secondary bile acid deficiency promotes intestinal inflammation

SR Sinha, Y Haileselassie, LP Nguyen, C Tropini… - Cell host & …, 2020 - cell.com
Secondary bile acids (SBAs) are derived from primary bile acids (PBAs) in a process reliant
on biosynthetic capabilities possessed by few microbes. To evaluate the role of BAs in …

Campylobacter jejuni promotes colorectal tumorigenesis through the action of cytolethal distending toxin

Z He, RZ Gharaibeh, RC Newsome, JL Pope… - Gut, 2019 - gut.bmj.com
Objective Campylobacter jejuni produces a genotoxin, cytolethal distending toxin (CDT),
which has DNAse activity and causes DNA double-strand breaks. Although C. jejuni …

Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome

Z Zhang, H Tang, P Chen, H Xie, Y Tao - Signal transduction and …, 2019 - nature.com
The trillions of microorganisms in the gut microbiome have attracted much attention recently
owing to their sophisticated and widespread impacts on numerous aspects of host …

Campylobacter jejuni: collective components promoting a successful enteric lifestyle

PM Burnham, DR Hendrixson - Nature Reviews Microbiology, 2018 - nature.com
Campylobacter jejuni is the leading cause of bacterial diarrhoeal disease in many areas of
the world. The high incidence of sporadic cases of disease in humans is largely due to its …

Bile acid-independent protection against Clostridioides difficile infection

AM Aguirre, N Yalcinkaya, Q Wu, A Swennes… - PLoS …, 2021 - journals.plos.org
Clostridioides difficile infections occur upon ecological/metabolic disruptions to the normal
colonic microbiota, commonly due to broad-spectrum antibiotic use. Metabolism of bile acids …

Campylobacter sp.: Pathogenicity factors and prevention methods—new molecular targets for innovative antivirulence drugs?

V Kreling, FH Falcone, C Kehrenberg… - Applied Microbiology and …, 2020 - Springer
Infections caused by bacterial species from the genus Campylobacter are one of the four
main causes of strong diarrheal enteritis worldwide. Campylobacteriosis, a typical food …

Gut microbiota-mediated secondary bile acid alleviates Staphylococcus aureus-induced mastitis through the TGR5-cAMP-PKA-NF-κB/NLRP3 pathways in mice

C Zhao, K Wu, H Hao, Y Zhao, L Bao, M Qiu… - NPJ biofilms and …, 2023 - nature.com
Although emerging evidence shows that gut microbiota-mediated metabolic changes
regulate intestinal pathogen invasions, little is known about whether and how gut microbiota …

A collection of bacterial isolates from the pig intestine reveals functional and taxonomic diversity

D Wylensek, TCA Hitch, T Riedel, A Afrizal… - Nature …, 2020 - nature.com
Our knowledge about the gut microbiota of pigs is still scarce, despite the importance of
these animals for biomedical research and agriculture. Here, we present a collection of …