To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …

The ability of epithelial cells to organize through cell–cell adhesion into a functioning
epithelium serves the purpose of a tight epithelial protective barrier. Contacts between …

Cancer is a key health issue across the world, causing substantial patient morbidity and
mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to …

Transforming growth factor-β (TGF-β) signaling is essential in embryo development and
maintaining normal homeostasis. Extensive evidence shows that TGF-β activation acts on …

Tight junctions (TJs) are intercellular protein complexes that preserve tissue homeostasis
and integrity through the control of paracellular permeability and cell polarity. Recent …

The different prostate cancer (PCa) cell populations (bulk and cancer stem cells, CSCs)
release exosomes that contain miRNAs that could modify the local or premetastatic niche …

Most cancer-related deaths come from metastasis. It was recently discovered that
nanoparticles could inhibit cancer cell migration. Whereas most researchers focus on single …

Over the last few years, the Transforming growth factor-β (TGF-β) has been significantly
considered as an effective and ubiquitous mediator of cell growth. The cytokine, TGF-β is …

Recent advancements in the field of cancer have established that the process of metastasis
is organ-specific with tumor cell dissemination occurring in the very early stages of disease …

Abstract Background Cancer-associated fibroblasts (CAFs) are a major component of the
cancer stroma, and their response to therapeutic treatments likely impacts the outcome. We …