Crystal engineering of pharmaceutical cocrystals in the discovery and development of improved drugs
The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …
reactions in the solid state. A broad chemical definition of crystal engineering was published …
Drug-drug and drug-nutraceutical cocrystal/salt as alternative medicine for combination therapy: a crystal engineering approach
R Thakuria, B Sarma - Crystals, 2018 - mdpi.com
The pre-formulation of pharmaceutical cocrystals and salts is a concept of crystal
engineering that has emerged as a promising technique for drug development in …
engineering that has emerged as a promising technique for drug development in …
A novel drug-drug cocrystal of levofloxacin and metacetamol: Reduced hygroscopicity and improved photostability of levofloxacin
T Shinozaki, M Ono, K Higashi, K Moribe - Journal of Pharmaceutical …, 2019 - Elsevier
Abstract Levofloxacin (LVFX), a broad-spectrum antibacterial agent from the fluoroquinolone
family, is universally prescribed with antipyretics, including paracetamol (APAP) analogs. In …
family, is universally prescribed with antipyretics, including paracetamol (APAP) analogs. In …
New forms of old drugs: improving without changing
S Domingos, V André, S Quaresma… - Journal of Pharmacy …, 2015 - academic.oup.com
Objectives In a short approach, we want to present the improvements that have recently
been done in the world of new solid forms of known active pharmaceutical ingredients …
been done in the world of new solid forms of known active pharmaceutical ingredients …
Drug-drug multicomponent solid forms: cocrystal, coamorphous and eutectic of three poorly soluble antihypertensive drugs using mechanochemical approach
J Haneef, R Chadha - AAPS PharmSciTech, 2017 - Springer
The present study deals with the application of mechanochemical approach for the
preparation of drug-drug multicomponent solid forms of three poorly soluble …
preparation of drug-drug multicomponent solid forms of three poorly soluble …
Hybrid and bioactive cocrystals of pyrazinamide with hydroxybenzoic acids: detailed study of structure, spectroscopic characteristics, other potential applications and …
JS Al-Otaibi, YS Mary, S Armaković… - Journal of Molecular …, 2020 - Elsevier
Three cocrystals of pyrazinamide (PYZ) with 2, 4-dihydroxy benzoic acid (2, 4HBA-PYZ), 2, 6-
dihydroxybenzoic acid (2, 6HBA-PYZ) and 3, 5-dihydroxybenzoic acid (3, 5HBA-PYZ) are …
dihydroxybenzoic acid (2, 6HBA-PYZ) and 3, 5-dihydroxybenzoic acid (3, 5HBA-PYZ) are …
Fast dissolving eutectic compositions of two anti-tubercular drugs
S Cherukuvada, A Nangia - CrystEngComm, 2012 - pubs.rsc.org
Co-crystallization of anti-tubercular drugs pyrazinamide (PZA) and isoniazid (INH) with each
other and with dicarboxylic acid coformers was studied. Grinding of the two drugs to make a …
other and with dicarboxylic acid coformers was studied. Grinding of the two drugs to make a …
Pharmaceutical cocrystals of diflunisal and diclofenac with theophylline
Pharmaceutical cocrystals of nonsteroidal anti-inflammatory drugs diflunisal (DIF) and
diclofenac (DIC) with theophylline (THP) were obtained, and their crystal structures were …
diclofenac (DIC) with theophylline (THP) were obtained, and their crystal structures were …
Mechanochemical synthesis of cocrystal: From mechanism to application
Y Xiao, C Wu, X Hu, K Chen, L Qi, P Cui… - Crystal Growth & …, 2023 - ACS Publications
Cocrystal engineering is gaining interest across various disciplines since it can effectively
tune the properties of solid substances via noncovalent synthesis by introducing new …
tune the properties of solid substances via noncovalent synthesis by introducing new …