N-linked glycosylation is a complex, co-and post-translational series of events that connects
metabolism to signaling in almost all cells. Metabolic assembly of N-linked glycans spans …

Homeostatic plasticity allows neural circuits to maintain an average activity level while
preserving the ability to learn new associations and efficiently transmit information. This …

Several neurodevelopmental and neuropsychiatric disorders are characterized by
intermittent episodes of pathological activity. Although genetic therapies offer the ability to …

Homeostatic synaptic plasticity is a process by which neurons adjust their synaptic strength
to compensate for perturbations in neuronal activity. Whether the highly diverse synapses on …

Neurons maintain their average firing rate and other properties within narrow bounds
despite changing conditions. This homeostatic regulation is achieved using negative …

Gene therapy for rare monogenetic neurological disorders is reaching clinics and offering
hope to families affected by these diseases. There is also potential for gene therapy to offer …

Abstract Purpose of Review To review the relationship between sleep, neurodevelopment,
and epilepsy and potential underlying physiological mechanisms. Recent Findings Recent …

The early stages of Alzheimer's disease (AD) have been linked to microcircuit dysfunction
and pathophysiological neuronal firing in several brain regions. Inhibitory GABAergic …

Epilepsy is caused when rhythmic neuronal network activity escapes normal control
mechanisms, resulting in seizures. There is an extensive and growing body of evidence that …

Epilepsy can be interpreted as altered brain rhythms from overexcitation or insufficient
inhibition. Chemogenetic tools have revolutionized neuroscience research because they …