Multimodal speech biomarkers for remote monitoring of ALS disease progression

M Neumann, H Kothare, V Ramanarayanan - Computers in Biology and …, 2024 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that
severely impacts affected persons' speech and motor functions, yet early detection and …

Which aspects of motor speech disorder are captured by Mel Frequency Cepstral Coefficients? Evidence from the change in STN-DBS conditions in Parkinson's …

V Illner, P Krýže, J Švihlík, M Sousa, P Krack… - Proceedings of the …, 2023 - dspace.cvut.cz
One of the most popular speech parametrizations for dysarthria has been Mel Frequency
Cepstral Coefficients (MFCCs). Although the MFCCs ability to capture vocal tract …

[PDF][PDF] When Words Speak Just as Loudly as Actions: Virtual Agent Based Remote Health Assessment Integrating What Patients Say with What They Do

V Ramanarayanan, D Pautler, L Arbatti… - Proc …, 2023 - vikramr.com
We present a unified multimodal dialog platform for the remote assessment and monitoring
of patients' neurological and mental health. Tina, a virtual agent, guides participants through …

Detection and Characterization of Autism Spectrum Disorder and Parkinson's Disease Utilizing Measures of Speech-and Fine-Motor Coordination

T Talkar - 2023 - search.proquest.com
Neurological disorders such as Autism Spectrum Disorder (ASD) and Parkinson's Disease
(PD) are typically associated with observed motor difficulties in speech production and in …

Listener effort quantifies clinically meaningful progression of dysarthria in people living with amyotrophic lateral sclerosis

I Navar Bingham, R Norel, EG Roitberg, J Peller… - medRxiv, 2024 - medrxiv.org
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative motor neuron disease that
causes progressive muscle weakness. Progressive bulbar dysfunction causes dysarthria …

[PDF][PDF] Multimodal Digital Biomarkers for Longitudinal Tracking of Speech Impairment Severity in ALS: An Investigation of Clinically Important Differences

M Neumann, H Kothare, J Liscombe… - Proc. Interspeech …, 2024 - researchgate.net
Speech biomarkers have shown promise for the remote assessment of ALS. However, to
demonstrate clinical utility at tracking longitudinal progress of the disease, one needs to …

Digital markers of motor speech impairments in spontaneous speech of patients with ALS-FTD spectrum disorders

S Shellikeri, S Cho, S Ash… - … Lateral Sclerosis and …, 2024 - Taylor & Francis
Objective To evaluate automated digital speech measures, derived from spontaneous
speech (picture descriptions), in assessing bulbar motor impairments in patients with ALS …

[HTML][HTML] Global Perspectives on the Management of Primary Progressive Aphasia

J Gallée, J Cartwright, S Grasso, R Jokel… - Research …, 2024 - ncbi.nlm.nih.gov
Speech-language therapists/pathologists (SLT/Ps) are key professionals in the management
and treatment of primary progressive aphasia (PPA), however, there are gaps in education …

Combining Multiple Multimodal Speech Features into an Interpretable Index Score for Capturing Disease Progression in Amyotrophic Lateral Sclerosis

M Neumann, H Kothare, V Ramanarayanan - Interspeech, 2023 - pmc.ncbi.nlm.nih.gov
Multiple speech biomarkers have been shown to carry useful information regarding
Amyotrophic Lateral Sclerosis (ALS) pathology. We propose a two-step framework to …

[PDF][PDF] Harnessing Speech Technology for Mental Health Assessment and Detection

C Bhat, SK Kopparapu - … SMM23, Workshop on Speech, Music and …, 2023 - isca-archive.org
One in eight people world wide live with some kind of mental disorder which results in
significant disturbances in their thinking and emotional behaviour. While effective prevention …