A-to-I RNA editing—immune protector and transcriptome diversifier
E Eisenberg, EY Levanon - Nature Reviews Genetics, 2018 - nature.com
Modifications of RNA affect its function and stability. RNA editing is unique among these
modifications because it not only alters the cellular fate of RNA molecules but also alters …
modifications because it not only alters the cellular fate of RNA molecules but also alters …
Naturally occurring modified ribonucleosides
PJ McCown, A Ruszkowska, CN Kunkler… - Wiley …, 2020 - Wiley Online Library
The chemical identity of RNA molecules beyond the four standard ribonucleosides has
fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in …
fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in …
RADAR: a rigorously annotated database of A-to-I RNA editing
G Ramaswami, JB Li - Nucleic acids research, 2014 - academic.oup.com
We present RADAR—a rigorously annotated database of A-to-I RNA editing (available at
http://RNAedit. com). The identification of A-to-I RNA editing sites has been dramatically …
http://RNAedit. com). The identification of A-to-I RNA editing sites has been dramatically …
The genomic landscape and clinical relevance of A-to-I RNA editing in human cancers
Summary Adenosine-to-inosine (A-to-I) RNA editing is a widespread post-transcriptional
mechanism, but its genomic landscape and clinical relevance in cancer have not been …
mechanism, but its genomic landscape and clinical relevance in cancer have not been …
[HTML][HTML] Reliable identification of genomic variants from RNA-seq data
R Piskol, G Ramaswami, JB Li - The American Journal of Human Genetics, 2013 - cell.com
Identifying genomic variation is a crucial step for unraveling the relationship between
genotype and phenotype and can yield important insights into human diseases. Prevailing …
genotype and phenotype and can yield important insights into human diseases. Prevailing …
Identifying RNA editing sites using RNA sequencing data alone
We show that RNA editing sites can be called with high confidence using RNA sequencing
data from multiple samples across either individuals or species, without the need for …
data from multiple samples across either individuals or species, without the need for …
Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs
CR Walkley, JB Li - Genome biology, 2017 - Springer
One of the most prevalent forms of post-transcritpional RNA modification is the conversion of
adenosine nucleosides to inosine (A-to-I), mediated by the ADAR family of enzymes. The …
adenosine nucleosides to inosine (A-to-I), mediated by the ADAR family of enzymes. The …
Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain
As a means to understand human neuropsychiatric disorders from human brain samples, we
compared the transcription patterns and histological features of postmortem brain to fresh …
compared the transcription patterns and histological features of postmortem brain to fresh …
Extensive recoding of the neural proteome in cephalopods by RNA editing
JJC Rosenthal, E Eisenberg - Annual Review of Animal …, 2023 - annualreviews.org
The coleoid cephalopods have the largest brains, and display the most complex behaviors,
of all invertebrates. The molecular and cellular mechanisms that underlie these remarkable …
of all invertebrates. The molecular and cellular mechanisms that underlie these remarkable …
Mitochondrial 16S rRNA is methylated by tRNA methyltransferase TRMT61B in all vertebrates
The mitochondrial ribosome, which translates all mitochondrial DNA (mtDNA)-encoded
proteins, should be tightly regulated pre-and post-transcriptionally. Recently, we found RNA …
proteins, should be tightly regulated pre-and post-transcriptionally. Recently, we found RNA …