Transposable elements (TEs) comprise about half of the mammalian genome. TEs often
contain sequences capable of recruiting the host transcription machinery, which they use to …

Spatiotemporal gene expression programmes are orchestrated by transcriptional
enhancers, which are key regulatory DNA elements that engage in physical contacts with …

Human endogenous retroviruses (HERVs) are abundant sequences that persist within the
human genome as remnants of ancient retroviral infections. These sequences became fixed …

Whereas folding of genomes at the large scale of epigenomic compartments and
topologically associating domains (TADs) is now relatively well understood, how chromatin …

Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery
drive cell division. Growing evidence indicates that this machinery operates in a distinct …

Chromatin architecture has been implicated in cell type-specific gene regulatory programs,
yet how chromatin remodels during development remains to be fully elucidated. Here, by …

The human genome contains more than 4.5 million inserts derived from transposable
elements (TEs), the result of recurrent waves of invasion and internal propagation …

Chromatin features are widely used for genome-scale mapping of enhancers. However,
discriminating active enhancers from other cis-regulatory elements, predicting enhancer …

Cell-type-and condition-specific profiles of gene expression require coordination between
protein-coding gene promoters and cis-regulatory sequences called enhancers. Enhancers …

Human pluripotent stem cells (hPSCs) are of fundamental relevance in regenerative
medicine. Naïve hPSCs hold promise to overcome some of the limitations of conventional …