Renin-angiotensin system in normal pregnancy and in preeclampsia: A comprehensive review

CRV Leal, LB Costa, GC Ferreira… - Pregnancy …, 2022 - Elsevier
The activation of the Renin Angiotensin System (RAS) is required during pregnancy and it
seems that RAS dysfunction has some important effects on pathological pregnancy …

[HTML][HTML] The placental exposome, placental epigenetic adaptations and lifelong cardio-metabolic health

JK Cleal, KR Poore, RM Lewis - Molecular Aspects of Medicine, 2022 - Elsevier
The placental exposome represents the sum of all placental exposures, and through its
influence on placental function can affect an individual's susceptibility to cardio-metabolic …

Alpha-2-macroglobulin is involved in the occurrence of early-onset pre-eclampsia via its negative impact on uterine spiral artery remodeling and placental …

J Wang, P Zhang, M Liu, Z Huang, X Yang, Y Ding… - BMC medicine, 2023 - Springer
Background Pre-eclampsia (PE) is one of the leading causes of maternal and fetal
morbidity/mortality during pregnancy, and alpha-2-macroglobulin (A2M) is associated with …

Physiological and pathological roles of Ang II and Ang-(1-7) in the female reproductive system

Y Liu, H Hao, T Lan, R Jia, M Cao, L Zhou… - Frontiers in …, 2022 - frontiersin.org
The local Renin-Angiotensin System (RAS) has been demonstrated to exist in a wide range
of tissues and organs, In the female reproductive system, it is mainly found in the ovary …

The Renin–Angiotensin System and Cardiovascular–Kidney–Metabolic Syndrome: Focus on Early-Life Programming

YL Tain, CN Hsu - International Journal of Molecular Sciences, 2024 - mdpi.com
The identification of pathological links among metabolic disorders, kidney ailments, and
cardiovascular conditions has given rise to the concept of cardiovascular–kidney–metabolic …

Serum vitamin D levels and COVID-19 during pregnancy: A systematic review and meta-analysis

S Mazaheri-Tehrani, MH Mirzapour, M Yazdi… - Clinical Nutrition …, 2022 - Elsevier
Background Serum vitamin D levels are reported to be associated with the risk of incidence
and severity of COVID-19 in the general population. During pregnancy, immune system …

Effects of Biological sex and pregnancy on SARS-CoV-2 pathogenesis and vaccine outcomes

JR Shapiro, CW Roberts, K Arcovio, L Reade… - Sex and Gender …, 2023 - Springer
SARS-CoV-2 is the causative agent of COVID-19 in humans and has resulted in the death of
millions of people worldwide. Similar numbers of infections have been documented in males …

Association of ACE2 gene functional variants with gestational diabetes mellitus risk in a southern Chinese population

G Huang, Q Liang, Y Wang, L Qin, H Yang… - Frontiers in …, 2022 - frontiersin.org
Objective To explore the relationship between angiotensin-converting enzyme 2 (ACE2)
genetic variants and gestational diabetes mellitus (GDM) in a southern Chinese population …

Implications of Pregnancy on Cardiometabolic Disease Risk: Preeclampsia and Gestational Diabetes

M Elgazzaz, PC Woodham, J Maher… - American Journal of …, 2024 - journals.physiology.org
Cardiometabolic disorders, such as obesity, insulin resistance and hypertension, prior to
and within pregnancy are increasing in prevalence worldwide. Pregnancy-associated …

The soluble (pro) renin receptor promotes a preeclampsia-like phenotype both in vitro and in vivo

LG Schofield, SJ Delforce, JC Pryor… - Hypertension …, 2024 - nature.com
Preeclampsia is classified as new-onset hypertension coupled with gross endothelial
dysfunction. Placental (pro) renin receptor ((P) RR) and plasma soluble (P) RR (s (P) RR) …