Neurodegenerative disease is a collective term given for the clinical condition, which results
in progressive degeneration of neurons and the loss of functions associated with the …

This overview of Parkinson's disease is designed to serve as a background to the discussion
elsewhere in this supplement on the pharmacotherapy used in its management. Parkinson's …

Parkinson's disease is a neurodegenerative disorder, and no treatment has been yet
established to prevent disease progression. Coenzyme Q10, an antioxidant, has been …

Abstract Background and Objectives Opicapone is a novel catechol-O-methyltransferase
(COMT) inhibitor. The purpose of this study was to evaluate the tolerability …

Background and purpose Opicapone (OPC) is a novel third generation catechol‐O‐
methyltransferase (COMT) inhibitor that enhances levodopa availability. This study …

Aims The aim of this study was to assess the tolerability, pharmacokinetics and inhibitory
effect on erythrocyte soluble catechol‐O‐methyltransferase (S‐COMT) activity following …

Background and objectives Opicapone is a novel third generation catechol-O-
methyltransferase (COMT) inhibitor. The purpose of this study was to compare the levodopa …

Background A combination of levodopa (L-DOPA) and carbidopa is the most commonly-
used treatment for symptom management in Parkinson's disease. Studies have shown that …

Aims To compare the levodopa/carbidopa (LC) and levodopa/benserazide (LB)
pharmacokinetic profiles following repeated doses of opicapone (OPC) administered apart …

Parkinson's disease is a neurodegenerative disease, the etiology of which remains
unknown, but some likely causes include oxidative stress, mitochondrial dysfunction and …