Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

Among other mechanisms, oxidative stress has been postulated to play an important role in
the rate of ageing. Oxidative damage contributes to the hallmarks of ageing and essential …

Cardiovascular disease is a leading cause of death and reduced quality of life, proven by
the latest data of the Global Burden of Disease Study, and is only gaining in prevalence …

Sarcopenia is a major component of the frailty syndrome, both being considered as strong
predictors of morbidity, disability, and death in older people. In this review, we explore the …

Biologists have long appreciated the critical role that energy turnover plays in understanding
variation in performance and fitness among individuals. Whole-organism metabolic studies …

With aging, the progressive loss of skeletal muscle will have negative effect on multiple
physiological parameters, such as exercise, respiration, thermoregulation, and metabolic …

Oxidative stress (OS) is primarily caused by the formation of free radicals and reactive
oxygen species; it is considered as one of the prominent factors in slowing down and …

Oxidative stress is characterized by an imbalance between prooxidant and antioxidant
species, leading to macromolecular damage and disruption of redox signaling and cellular …

Peroxisomes are cell organelles that play a central role in lipid metabolism. At the same
time, these organelles generate reactive oxygen and nitrogen species as byproducts …

Coumarin compounds represent an important type of naturally occurring and synthetic
oxygen-containing heterocycles with typical benzopyrone framework. This type of special …