E-cadherin is a single-pass transmembrane protein that mediates homophilic cell–cell
interactions. Tumour progression is often associated with the loss of E-cadherin function and …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

Intercellular junctions mediate adhesion and communication between adjoining endothelial
and epithelial cells. In the endothelium, junctional complexes comprise tight junctions …

Vascular endothelial (VE)-cadherin is a strictly endothelial specific adhesion molecule
located at junctions between endothelial cells. In analogy of the role of E-cadherin as major …

How vascular endothelial growth factor (VEGF) induces vascular permeability, its first
described function, remains poorly understood. Here, we provide evidence of a novel …

Transforming growth factor-β1 (TGF-β) can be tumor suppressive, but it can also enhance
tumor progression by stimulating the complex process of epithelial-to-mesenchymal …

We have found that epithelial cells engage in a process of cadherin-mediated intercellular
adhesion that utilizes calcium and actin polymerization in unexpected ways. Calcium …

Tight junctions have long been regarded as simple barriers that separate compartments of
different compositions, but recent research indicates that different types of signalling proteins …

The endothelium forms a selective semi-permeable barrier controlling bidirectional transfer
between blood vessel and irrigated tissues. This crucial function relies on the dynamic …

Statins have been prescribed extensively for their cholesterol-lowering properties and
efficacy in cardiovascular disease. However, compelling evidence now exists that statins …