The known genetic architecture of blood pressure now comprises> 30 genes, with rare
variants resulting in monogenic forms of hypertension or hypotension and> 1,477 common …

Alcohol use disorders (AUDs) are complex traits, meaning that variations in many genes
contribute to the risk, as does the environment. Although the total genetic contribution to risk …

Nonalcoholic fatty liver disease (NAFLD) is common and partially heritable and has no
effective treatments. We carried out a genome-wide association study (GWAS) meta …

Liability to alcohol dependence (AD) is heritable, but little is known about its complex
polygenic architecture or its genetic relationship with other disorders. To discover loci …

Objective: Alcohol use disorders are common conditions that have enormous social and
economic consequences. Genome-wide association analyses were performed to identify …

Alcohol consumption has been linked to over 200 diseases and is responsible for over 5%
of the global disease burden. Well-known genetic variants in alcohol metabolizing genes, for …

Objective To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as
an instrument to investigate the causal role of alcohol in cardiovascular disease. Design …

Esophageal squamous cell carcinoma (ESCC) shows remarkable variation in incidence that
is not fully explained by known lifestyle and environmental risk factors. It has been …

Alcohol use disorder (AUD) is a highly prevalent, comorbid, and disabling disorder. The
underlying mechanism of ethanol neurotoxicity and the involvement of oxidative stress is still …

Background Substance use disorder (SUD) remains a significant public health issue. A
greater understanding of how genes and environment interact to regulate phenotypes …