A considerable number of human diseases have an inflammatory component, and a key
mediator of immune activation and inflammation is inducible nitric oxide synthase (iNOS) …

This review concentrates on advances in nitric oxide synthase (NOS) structure, function and
inhibition made in the last seven years, during which time substantial advances have been …

Heart failure with preserved ejection fraction (HFpEF) is a common syndrome with high
morbidity and mortality for which there are no evidence-based therapies. Here we report that …

Chimeric antigen receptor (CAR) therapy targeting CD19 is an effective treatment for
refractory B cell malignancies, especially acute lymphoblastic leukemia (ALL) 1. Although a …

Mutagenesis of the host immune system has helped identify response pathways necessary
to combat tuberculosis. Several such pathways may function as activators of a common …

Nitric oxide (NO) plays a critical role in vascular endothelial growth factor (VEGF)-induced
angiogenesis and vascular hyperpermeability. However, the relative contribution of different …

Alzheimer disease (AD) is a neurodegenerative disorder in which oxidative stress is a key
hallmark. It occurs early in disease pathogenesis and can exacerbate its progression …

Varicocele is recognized as the leading cause of male infertility because it can impair
spermatogenesis through several distinct pathophysiological mechanisms. Current …

Chronic obstructive pulmonary disease (COPD) is one of the most common causes of death
worldwide. We report in an emphysema model of mice chronically exposed to tobacco …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …