Protein function depends on transitions from the ground state to higher energy states.
Deviations from the ground-state structure result from chemical reactivity and conformational …

This review surveys recent investigations of conformational fluctuations of proteins in
solution using NMR techniques. Advances in experimental methods have provided more …

Liquid–liquid phase separation (LLPS) is involved in the formation of membraneless
organelles (MLOs) associated with RNA processing. The RNA-binding protein TDP-43 is …

The nucleolus is a membrane-less organelle formed through liquid-liquid phase separation
of its components from the surrounding nucleoplasm. Here, we show that nucleophosmin …

Nuclear magnetic resonance (NMR) is widely used across many fields of science because
of the rich data it produces, and some of the most valuable data come from studies of …

The perspective reviews quantitative investigations of chemical exchange phenomena in
proteins and other biological macromolecules using NMR spectroscopy, particularly …

Over the past 15 years there has been an explosion of research on the dynamical properties
of proteins, largely driven by the emergence of a handful of techniques that are sensitive to …

Time-dependent dynamical properties of molecules can be quantified with atomic resolution
by using solution-state NMR spectroscopy. A variety of NMR observables, including scalar …

▪ Abstract NMR spin relaxation spectroscopy is a powerful approach for characterizing
intramolecular and overall rotational motions in proteins. This review describes experimental …

The static magnetic field dependence of chemical exchange linebroadening in NMR
spectroscopy is investigated theoretically and experimentally. Two-site exchange (A⇆ B) is …