Overview of the 2022 WHO classification of neuroendocrine neoplasms

G Rindi, O Mete, S Uccella, O Basturk, S La Rosa… - Endocrine …, 2022 - Springer
In this review, we detail the changes and the relevant features that are applied to
neuroendocrine neoplasms (NENs) in the 2022 WHO Classification of Endocrine and …

The impact of SARS-Cov-2 virus infection on the endocrine system

NP Somasundaram, I Ranathunga… - Journal of the …, 2020 - academic.oup.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has spread across
the globe rapidly causing an unprecedented pandemic. Because of the novelty of the …

First-in-humans study of the SSTR antagonist 177Lu-DOTA-LM3 for peptide receptor radionuclide therapy in patients with metastatic neuroendocrine neoplasms …

RP Baum, J Zhang, C Schuchardt… - Journal of Nuclear …, 2021 - Soc Nuclear Med
The objective of this study was to assess the safety, dosimetry, and efficacy of the 177Lu-
labeled somatostatin receptor (SSTR) antagonist DOTA-p-Cl-Phe-cyclo (d-Cys-Tyr-d-4 …

[HTML][HTML] The new WHO classification of gastrointestinal neuroendocrine tumors and immunohistochemical expression of somatostatin receptor 2 and 5

O Popa, SM Taban, S Pantea… - Experimental and …, 2021 - spandidos-publications.com
Abstract The 2019 World Health Organization (WHO) classification of gastrointestinal tumors
defines well‑differentiated grade 3 neuroendocrine tumors, the mixed neuroendocrine‑non …

[HTML][HTML] The evolution of PRRT for the treatment of neuroendocrine tumors; What comes next?

PE Harris, K Zhernosekov - Frontiers in Endocrinology, 2022 - frontiersin.org
Lu-177 has been developed for the treatment of patients with peptide receptor radionuclide
therapy (PRRT). A second generation pure no-carrier-added Lu-177 has a high specific …

[HTML][HTML] Epigenetic regulation of somatostatin and somatostatin receptors in neuroendocrine tumors and other types of cancer

MJ Klomp, SU Dalm, M De Jong, RA Feelders… - Reviews in Endocrine …, 2021 - Springer
Both somatostatin (SST) and somatostatin receptors (SSTRs) are proteins with important
functions in both physiological tissue and in tumors, particularly in neuroendocrine tumors …

Peptide receptor radionuclide therapy

J Hofland, T Brabander, FA Verburg… - The Journal of …, 2022 - academic.oup.com
The concept of using a targeting molecule labeled with a diagnostic radionuclide for using
positron emission tomography or single photon emission computed tomography imaging …

[HTML][HTML] The complex histopathological and immunohistochemical spectrum of neuroendocrine tumors—an overview of the latest classifications

AA Gheorghișan-Gălățeanu, A Ilieșiu… - International Journal of …, 2023 - mdpi.com
Neuroendocrine neoplasms (NENs) originate from the neuroendocrine cell system, which
may either take the shape of organoid cell aggregations or be composed of dispersed cells …

[HTML][HTML] Gastrinoma

RT Jensen, T Ito - Endotext [Internet], 2023 - ncbi.nlm.nih.gov
Gastrinomas are neuroendocrine neoplasms (NENs), that occur primarily in the duodenum
and pancreas, which ectopically secrete gastrin, resulting in the Zollinger-Ellison syndrome …

[HTML][HTML] A comprehensive review on neuroendocrine neoplasms: presentation, pathophysiology and management

Q Sultana, J Kar, A Verma, S Sanghvi, N Kaka… - Journal of Clinical …, 2023 - mdpi.com
Neuroendocrine neoplasms (NENs) are a group of heterogeneous tumors with
neuroendocrine differentiation that can arise from any organ. They account for 2% of all …