Role of chemokine systems in cancer and inflammatory diseases

H Li, M Wu, X Zhao - MedComm, 2022 - Wiley Online Library
Chemokines are a large family of small secreted proteins that have fundamental roles in
organ development, normal physiology, and immune responses upon binding to their …

Mechanism of action of certain medicinal plants for the treatment of asthma

K Usmani, SK Jain, S Yadav - Journal of Ethnopharmacology, 2023 - Elsevier
Ethnopharmacological relevance Asthma is often treated and prevented using the
pharmacological properties of traditional medicinal plants. These healthcare systems are …

Smoking changes adaptive immunity with persistent effects

V Saint-André, B Charbit, A Biton, V Rouilly… - Nature, 2024 - nature.com
Individuals differ widely in their immune responses, with age, sex and genetic factors having
major roles in this inherent variability,,,,–. However, the variables that drive such differences …

Single-cell and spatial transcriptome analysis reveals the cellular heterogeneity of liver metastatic colorectal cancer

F Wang, J Long, L Li, ZX Wu, TT Da, XQ Wang… - Science …, 2023 - science.org
In this study, we comprehensively charted the cellular landscape of colorectal cancer (CRC)
and well-matched liver metastatic CRC using single-cell and spatial transcriptome RNA …

Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology

GS Gullotta, D De Feo, E Friebel, A Semerano… - Nature …, 2023 - nature.com
Aging accounts for increased risk and dismal outcome of ischemic stroke. Here, we
investigated the impact of age-related changes in the immune system on stroke. Upon …

Human umbilical cord mesenchymal stem cell-derived exosomes promote murine skin wound healing by neutrophil and macrophage modulations revealed by single …

Y Liu, M Zhang, Y Liao, H Chen, D Su, Y Tao… - Frontiers in …, 2023 - frontiersin.org
Introduction Full-thickness skin wound healing remains a serious undertaking for patients.
While stem cell-derived exosomes have been proposed as a potential therapeutic approach …

Integrating bulk and single-cell sequencing reveals the phenotype-associated cell subpopulations in sepsis-induced acute lung injury

F Wang, M Chen, J Ma, C Wang, J Wang… - Frontiers in …, 2022 - frontiersin.org
The dysfunctional immune response and multiple organ injury in sepsis is a recurrent theme
impacting prognosis and mortality, while the lung is the first organ invaded by sepsis. To …

Revisiting asthma pharmacotherapy: where do we stand and where do we want to go?

M Cazzola, CP Page, MG Matera… - European …, 2023 - Eur Respiratory Soc
Several current guidelines/strategies outline a treatment approach to asthma, which
primarily consider the goals of improving lung function and quality of life and reducing …

CXC chemokines in the pathogenesis of pulmonary disease and pharmacological relevance

K Komolafe, M Pacurari - International journal of inflammation, 2022 - Wiley Online Library
Chemokines and their receptors play important roles in the pathophysiology of many
diseases by regulating the cellular migration of major inflammatory and immune players …

Abnormal adenosine metabolism of neutrophils inhibits airway inflammation and remodeling in asthma model induced by Aspergillus fumigatus

T Liu, Y Wang, Z Zhang, L Jia, J Zhang, S Zheng… - BMC Pulmonary …, 2023 - Springer
Background Neutrophils consume a large amount of energy when performing their
functions. Compared with other white blood cells, neutrophils contain few mitochondria and …