Mechanisms and regulation of endothelial VEGF receptor signalling

M Simons, E Gordon, L Claesson-Welsh - Nature reviews Molecular …, 2016 - nature.com
Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are uniquely
required to balance the formation of new blood vessels with the maintenance and …

Biological functions of lymphatic vessels

TV Petrova, GY Koh - Science, 2020 - science.org
BACKGROUND Blood and lymphatic vessel networks form two arms of the vertebrate
cardiovascular system that play complementary roles in body homeostasis maintenance and …

[HTML][HTML] Lymphatic vessel network structure and physiology

JW Breslin, Y Yang, JP Scallan, RS Sweat… - Comprehensive …, 2018 - ncbi.nlm.nih.gov
The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue,
which has the holistic function to maintain the local physiologic environment for every cell in …

Intestinal lymphatic vasculature: structure, mechanisms and functions

J Bernier-Latmani, TV Petrova - Nature reviews Gastroenterology & …, 2017 - nature.com
The mammalian intestine is richly supplied with lymphatic vasculature, which has functions
ranging from maintenance of interstitial fluid balance to transport of antigens, antigen …

Systematic review of lymphovenous anastomosis (LVA) for the treatment of lymphedema

MF Scaglioni, DBY Fontein, M Arvanitakis… - …, 2017 - Wiley Online Library
Introduction Lymphedema is a chronic condition caused by the obstruction or impairment of
lymphatic fluid transport resulting in irreversible skin fibrosis. Besides conservative therapy …

Epsin nanotherapy regulates cholesterol transport to fortify atheroma regression

K Cui, X Gao, B Wang, H Wu, K Arulsamy… - Circulation …, 2023 - Am Heart Assoc
Background: Excess cholesterol accumulation in lesional macrophages elicits complex
responses in atherosclerosis. Epsins, a family of endocytic adaptors, fuel the progression of …

Regulation of VEGFR signalling in lymphatic vascular development and disease: an update

GA Secker, NL Harvey - International Journal of Molecular Sciences, 2021 - mdpi.com
The importance of lymphatic vessels in a myriad of human diseases is rapidly gaining
recognition; lymphatic vessel dysfunction is a feature of disorders including congenital …

[HTML][HTML] Development and aging of the lymphatic vascular system

A González-Loyola, TV Petrova - Advanced Drug Delivery Reviews, 2021 - Elsevier
The lymphatic vasculature has a pivotal role in regulating body fluid homeostasis, immune
surveillance and dietary fat absorption. The increasing number of in vitro and in vivo studies …

Promoting lymphangiogenesis and lymphatic growth and remodeling to treat cardiovascular and metabolic diseases

X Liu, K Cui, H Wu, KS Li, Q Peng, D Wang… - … , and vascular biology, 2023 - Am Heart Assoc
Lymphatic vessels are low-pressure, blind-ended tubular structures that play a crucial role in
the maintenance of tissue fluid homeostasis, immune cell trafficking, and dietary lipid uptake …

Lymphangiogenesis guidance by paracrine and pericellular factors

K Vaahtomeri, S Karaman, T Mäkinen… - Genes & …, 2017 - genesdev.cshlp.org
Lymphatic vessels are important for tissue fluid homeostasis, lipid absorption, and immune
cell trafficking and are involved in the pathogenesis of several human diseases. The …