Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

Background: Patients with substantive bleeding usually require transfusion and/or (re-)
operation. Red blood cell (RBC) transfusion is independently associated with a greater risk …

Introduction The understanding of coagulopathies in trauma has increased interest in
thromboelastography (TEG®) and thromboelastometry (ROTEM®), which promptly evaluate …

BACKGROUND Fibrinolysis is a physiologic process maintaining patency of the
microvasculature. Maladaptive overactivation of this essential function (hyperfibrinolysis) is …

Uncontrolled massive bleeding with subsequent derangement of the coagulation system is a
major challenge in the management of both surgical and seriously injured patients. Under …

Background Fibrinolysis is a physiologic process that maintains microvascular patency by
breaking down excessive fibrin clot. Hyperfibrinolysis is associated with a doubling of …

Fibrinolysis is a physiologic component of hemostasis that functions to limit clot formation.
However, following trauma or surgery excessive fibrinolysis may contribute to coagulopathy …

Trauma remains the leading cause of death with bleeding as the primary cause of
preventable mortality during the first 24 h following trauma. When death occurs, it happens …

Further advances in TIC treatment require an enhanced understanding of the dynamic
changes in the equilibrium between pro and anticoagulant factors, downstream effectors …

The CRASH-2 trial results have prompted trauma centers to contemplate whether
tranexamic acid (TXA) should be added to their armamentarium for the treatment of bleeding …