[HTML][HTML] Drug repurposing for next-generation combination therapies against multidrug-resistant bacteria

Y Liu, Z Tong, J Shi, R Li, M Upton, Z Wang - Theranostics, 2021 - ncbi.nlm.nih.gov
Antimicrobial resistance has been a global health challenge that threatens our ability to
control and treat life-threatening bacterial infections. Despite ongoing efforts to identify new …

Antibiotic resistant bacteria: current situation and treatment options to accelerate the development of a new antimicrobial arsenal

A Tarín-Pelló, B Suay-García… - Expert Review of Anti …, 2022 - Taylor & Francis
Introduction Antibiotic resistance is one of the biggest public health threats worldwide.
Currently, antibiotic-resistant bacteria kill 700,000 people every year. These data represent …

[HTML][HTML] Human serum triggers antibiotic tolerance in Staphylococcus aureus

EVK Ledger, S Mesnage, AM Edwards - Nature Communications, 2022 - nature.com
Staphylococcus aureus frequently causes infections that are challenging to treat, leading to
high rates of persistent and relapsing infection. Here, to understand how the host …

β-Lactams against the Fortress of the Gram-Positive Staphylococcus aureus Bacterium

JF Fisher, S Mobashery - Chemical reviews, 2020 - ACS Publications
The biological diversity of the unicellular bacteria—whether assessed by shape, food,
metabolism, or ecological niche—surely rivals (if not exceeds) that of the multicellular …

[HTML][HTML] Polymyxins, the last-resort antibiotics: Mode of action, resistance emergence, and potential solutions

SS Mohapatra, SK Dwibedy, I Padhy - Journal of Biosciences, 2021 - Springer
Infections caused by multi-drug resistant (MDR) bacterial pathogens are a leading cause of
mortality and morbidity across the world. Indiscriminate use of broad-spectrum antibiotics …

Preparation and antibiofilm studies of curcumin loaded chitosan nanoparticles against polymicrobial biofilms of Candida albicans and Staphylococcus aureus

S Ma, D Moser, F Han, M Leonhard… - Carbohydrate …, 2020 - Elsevier
Polymicrobial biofilms related infections are an important clinical problem with classical
antibiotics being not sufficient in therapy. Here, curcumin (Cur) was loaded on positively …

Controlling biofilm and virulence properties of Gram-positive bacteria by targeting wall teichoic acid and lipoteichoic acid

GJ Jeong, F Khan, N Tabassum, KJ Cho… - International Journal of …, 2023 - Elsevier
Wall teichoic acid (WTA) and lipoteichoic acid (LTA) are structural components of Gram-
positive bacteria's peptidoglycan and cell membrane, which are mostly anionic …

[HTML][HTML] Recent advances in strategies to combat bacterial drug resistance: antimicrobial materials and drug delivery systems

J Yao, P Zou, Y Cui, L Quan, C Gao, Z Li, W Gong… - Pharmaceutics, 2023 - mdpi.com
Bacterial infection is a common clinical disease. Antibiotics have saved countless lives since
their discovery and are a powerful weapon in the fight against bacteria. However, with the …

Glucose-metabolism-triggered colorimetric sensor array for point-of-care differentiation and antibiotic susceptibility testing of bacteria

X Zhou, H Wu, X Chen, W Li, J Zhang, M Wang… - Food Chemistry, 2024 - Elsevier
Simple and sensitive discrimination of multiple bacteria and antimicrobial susceptibility test
(AST) are significant for food safety, clinical diagnosis and treatment. Herein, based on …

[HTML][HTML] Modulation of MRSA virulence gene expression by the wall teichoic acid enzyme TarO

Y Lu, F Chen, Q Zhao, Q Cao, R Chen, H Pan… - Nature …, 2023 - nature.com
Phenol-soluble modulins (PSMs) and Staphylococcal protein A (SpA) are key virulence
determinants for community-associated methicillin-resistant Staphylococcus aureus (CA …