When to start and stop bone-protecting medication for preventing glucocorticoid-induced osteoporosis

KN Hayes, U Baschant, B Hauser, AM Burden… - Frontiers in …, 2021 - frontiersin.org
Glucocorticoid-induced osteoporosis (GIOP) leads to fractures in up to 40% of patients with
chronic glucocorticoid (GC) therapy when left untreated. GCs rapidly increase fracture risk …

Glucocorticoids in rheumatoid arthritis: Balancing benefits and harm by leveraging the therapeutic window of opportunity

M Doumen, S Pazmino, D Bertrand, R Westhovens… - Joint Bone Spine, 2023 - Elsevier
Glucocorticoids have been available since the early 1950s and have since become an
integral part of the management of rheumatoid arthritis (RA). Due to their rapid effect …

Bone Loss in Inflammatory Rheumatic Musculoskeletal Disease Patients Treated With Low‐Dose Glucocorticoids and Prevention by Anti‐Osteoporosis Medications

G Adami, A Fassio, M Rossini, C Benini… - Arthritis & …, 2023 - Wiley Online Library
Objective The negative effects of glucocorticoids on bone depend on dose and treatment
duration. However, it is unclear whether a safe dose exists, especially for patients with …

Biological disease-modifying antirheumatic drugs and osteoporotic fracture risk in patients with rheumatoid arthritis: a Danish cohort study

S Abtahi, R Cordtz, L Dreyer, JHM Driessen… - The American Journal of …, 2022 - Elsevier
Objectives Clinical trials have shown a beneficial effect from biological disease-modifying
antirheumatic drugs (bDMARDs) on hand or axial bone loss in patients with rheumatoid …

Damaged bone microarchitecture by Trabecular Bone Score (TBS) and low appendicular muscle mass: main risk factors for vertebral and non-vertebral fractures in …

FF Silva, GR Machado, ACM Ribeiro… - Osteoporosis …, 2024 - Springer
We ascertained the fracture risk factors stratified by vertebral and non-vertebral sites in
rheumatoid arthritis (RA) females. Bone/muscle features, but not disease activity, were the …

High incidence of clinical fragility fractures in postmenopausal women with rheumatoid arthritis. A case-control study

C Gómez-Vaquero, JL Hernández, JM Olmos, D Cerdà… - Bone, 2023 - Elsevier
Objectives To estimate the incidence of clinical fragility fractures in postmenopausal women
with rheumatoid arthritis (RA) and analyze risk factors for fracture. Methods Incidence of …

Systematic review for the treatment of older rheumatoid arthritis patients informing the 2020 update of the Japan College of Rheumatology clinical practice guidelines …

T Sugihara, Y Kawahito, A Morinobu… - Modern …, 2022 - academic.oup.com
Objectives To provide an evidence base for clinical practice guidelines (CPG) for the
management of rheumatoid arthritis (RA) in older adults. Methods PubMed, Cochrane …

Osteoporosis and fracture risk are multifactorial in patients with inflammatory rheumatic diseases

F Buttgereit, A Palmowski, M Bond, G Adami… - Nature Reviews …, 2024 - nature.com
Patients with inflammatory rheumatic and musculoskeletal diseases (iRMDs) such as
rheumatoid arthritis, connective tissue diseases, vasculitides and spondyloarthropathies are …

The safety of glucocorticoids in the treatment of inflammatory rheumatic disease: new evidence

M Luís, M Boers, K Saag, F Buttgereit… - Current Opinion in …, 2022 - journals.lww.com
Based on current evidence the benefit–risk balance of low-dose glucocorticoids in
rheumatoid arthritis, and probably in other rheumatic diseases is generally favourable …

Personalized therapeutic strategies in the management of osteoporosis in patients with autoantibody-positive rheumatoid arthritis

B D'Onofrio, M di Lernia, L De Stefano… - Journal of Clinical …, 2022 - mdpi.com
Bone mineral density (BMD) reduction and fragility fractures still represent a major source of
morbidity in rheumatoid arthritis (RA) patients, despite adequate control of the disease. An …