Alcohol-associated liver disease

B Mackowiak, Y Fu, L Maccioni… - The Journal of Clinical …, 2024 - Am Soc Clin Investig
Alcohol-associated liver disease (ALD) is a major cause of chronic liver disease worldwide,
and comprises a spectrum of several different disorders, including simple steatosis …

Experimental models of fatty liver diseases: Status and appraisal

H Wang, H Shen, W Seo, S Hwang - Hepatology Communications, 2023 - journals.lww.com
Fatty liver diseases, including alcohol-associated liver disease (ALD) and nonalcoholic fatty
liver disease nonalcoholic fatty liver disease (NAFLD), affect a large number of people …

Homogeneous heterophase junction based on cubic/orthomorphic SnS for chemiresistive room temperature trace-ethanol sensor

Y Qin, Y Liang, C Zhou, Y Bai - Sensors and Actuators B: Chemical, 2024 - Elsevier
Herein, we developed a homogeneous heterophase structure based on the
stereochemically-active cubic/orthorhombic SnS (CUB/ORT-SnS) by chemical precipitation …

[HTML][HTML] Water extracts of Pueraria thomsonii Radix ameliorates alcoholic liver disease via PI3K/AKT and NOX4/ROS pathways

K Yang, X Zhang, D Liu, S Wen, Y Wu, T Li… - Journal of Functional …, 2023 - Elsevier
Pueraria thomsonii Radix. as an important edible and medicinal plant in China, its effects
and mechanisms on alcoholic liver disease (ALD) remain unclear. Herein, we investigated …

Coagulation Dysfunctions in Non-Alcoholic Fatty Liver Disease—Oxidative Stress and Inflammation Relevance

MA Robea, IM Balmus, I Girleanu, L Huiban, C Muzica… - Medicina, 2023 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases. Its
incidence is progressively rising and it is possibly becoming a worldwide epidemic. NAFLD …

Coordinated action of a gut–liver pathway drives alcohol detoxification and consumption

Y Fu, B Mackowiak, YH Lin, L Maccioni, T Lehner… - Nature …, 2024 - nature.com
Alcohol use disorder (AUD) affects millions of people worldwide, causing extensive
morbidity and mortality with limited pharmacological treatments. The liver is considered as …

Gut-liver Axis: Recent concepts in pathophysiology in alcohol-associated liver disease

FR Tonetti, A Eguileor, M Mrdjen, V Pathak… - Hepatology, 2024 - journals.lww.com
The growing recognition of the role of the gut microbiome's impact on alcohol-related
diseases, especially in alcohol-associated liver disease, emphasizes the need to …

Dysregulated pancreatic lipid phenotype, inflammation and cellular injury in a chronic ethanol feeding model of hepatic alcohol dehydrogenase-deficient deer mice

MP Srinivasan, KK Bhopale, AA Caracheo, L Kaphalia… - Life Sciences, 2023 - Elsevier
Aims Dysregulation of pancreatic fat and lipotoxic inflammation are common clinical findings
in alcoholic chronic pancreatitis (ACP). In this study, we investigated a relationship between …

Hepatocyte-specific mitogen-activated protein kinase phosphatase 1 in sexual dimorphism and susceptibility to alcohol induced liver injury

MN Walter, D Montoya-Durango, W Rodriguez… - Frontiers in …, 2024 - frontiersin.org
Background It is well established that females are more susceptible to the toxic effects of
alcohol, although the exact mechanisms are still poorly understood. Previous studies noted …

Hepatic Transcriptome and Its Regulation Following Soluble Epoxide Hydrolase Inhibition in Alcohol-Associated Liver Disease

JB Warner, JE Hardesty, YL Song, AT Floyd… - The American Journal of …, 2024 - Elsevier
Alcohol-associated liver disease (ALD) is a serious public health problem with limited
pharmacologic options. The goal of the current study was to investigate the efficacy of …