Abstract Calcium (Ca2+) signalling is of paramount importance to immunity. Regulated
increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex …

Molecular, cellular, and clinical studies of human inborn errors of immunity have
revolutionized our understanding of their pathogenesis, considerably broadened their …

Abstract The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate
the genetic architecture and biology of heart, lung, blood and sleep disorders, with the …

Dental enamel is the hardest and most mineralized tissue in extinct and extant vertebrate
species and provides maximum durability that allows teeth to function as weapons and/or …

Calcium (Ca2+) is an essential signaling molecule that controls a wide range of biological
functions. In the immune system, calcium signals play a central role in a variety of cellular …

Metals are essential components in all forms of life required for the function of nearly half of
all enzymes and are critically involved in virtually all fundamental biological processes …

Stimulator of interferon genes (STING) is an endoplasmic reticulum (ER) signaling adaptor
that is essential for the type I interferon response to DNA pathogens. Aberrant activation of …

Calcium (Ca 2+) signals play fundamental roles in immune cell function. The main sources
of Ca 2+ influx in mammalian lymphocytes following antigen receptor stimulation are Ca 2+ …

T cell antigen-receptor (TCR) signaling controls the development, activation and survival of
T cells by involving several layers and numerous mechanisms of gene regulation. N 6 …

Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …