Human exposure to neonicotinoid insecticides and the evaluation of their potential toxicity: An overview

W Han, Y Tian, X Shen - Chemosphere, 2018 - Elsevier
Neonicotinoid insecticides have become the fastest growing class of insecticides over the
past few decades. The insecticidal activity of neonicotinoids is attributed to their agonist …

Neurotoxic effects of neonicotinoids on mammals: what is there beyond the activation of nicotinic acetylcholine receptors?—A systematic review

C Costas-Ferreira, LRF Faro - International Journal of Molecular Sciences, 2021 - mdpi.com
Neonicotinoids are a class of insecticides that exert their effect through a specific action on
neuronal nicotinic acetylcholine receptors (nAChRs). The success of these insecticides is …

NOAEL-dose of a neonicotinoid pesticide, clothianidin, acutely induce anxiety-related behavior with human-audible vocalizations in male mice in a novel environment

T Hirano, S Yanai, T Takada, N Yoneda, T Omotehara… - Toxicology Letters, 2018 - Elsevier
Neonicotinoids are novel systemic pesticides acting as agonists on the nicotinic
acetylcholine receptors (nAChRs) of insects. Experimental studies have revealed that …

The combined effect of clothianidin and environmental stress on the behavioral and reproductive function in male mice

T Hirano, S Yanai, T Omotehara… - Journal of Veterinary …, 2015 - jstage.jst.go.jp
Neonicotinoids, some of the most widely used pesticides in the world, act as agonists to the
nicotinic acetylcholine receptors (nAChRs) of insects, resulting in death from abnormal …

Growth and neurite stimulating effects of the neonicotinoid pesticide clothianidin on human neuroblastoma SH-SY5Y cells

T Hirano, S Minagawa, Y Furusawa, T Yunoki… - Toxicology and Applied …, 2019 - Elsevier
Neonicotinoids are one of most widely used pesticides targeting nicotinic acetylcholine
receptors (nAChRs) of insects. Recent epidemiological evidence revealed increasing …

Peripubertal exposure to the neonicotinoid pesticide dinotefuran affects dopaminergic neurons and causes hyperactivity in male mice

N Yoneda, T Takada, T Hirano, S Yanai… - Journal of Veterinary …, 2018 - jstage.jst.go.jp
Although neonicotinoid pesticides are expected to have harmful influence on mammals,
there is little animal experimental data to support the effect and mechanisms. Since …

Neurotoxicity of neonicotinoids

A Anadón, I Ares, M Martínez… - Advances in …, 2020 - Elsevier
Neonicotinoids are the most important new class of synthetic insecticides used in plant and
animal health over the last decade to control sucking insects. The main marketed …

Elucidation of the neurological effects of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) using two-photon microscopy in vivo imaging

M Nishi, S Sugio, T Hirano, D Kato, H Wake… - Journal of Veterinary …, 2022 - jstage.jst.go.jp
Neonicotinoid pesticides (NNs) cause behavioral abnormalities in mammals, raising
concerns about their effects on neural circuit activity. We herein examined the neurological …

[HTML][HTML] Acute thiamethoxam exposure induces hepatotoxicity and neurotoxicity in juvenile Chinese mitten crab (Eriocheir sinensis)

Y Yang, Q Yu, C Zhang, X Wang, L He, Y Huang… - Ecotoxicology and …, 2023 - Elsevier
The similar nervous system structure between crustaceans and insects and the high-water
solubility of thiamethoxam can lead to the more severe toxicity of thiamethoxam to …

An integrated approach, based on mass spectrometry, for the assessment of imidacloprid metabolism and penetration into mouse brain and fetus after oral treatment

A Passoni, A Mariani, D Comolli, R Fanelli, E Davoli… - Toxicology, 2021 - Elsevier
Imidacloprid is an insecticide belonging to neonicotinoids, a class of agonists of the nicotinic
acetylcholine receptors that shows higher affinities in insects compared to mammals …