The allene functionality has participated in one of the most exciting voyages in organic
chemistry, from chemical curiosities to a recurring building block in modern organic …

We report the stereoselective total synthesis of rhodocoranes I and J in 10 steps and 16.4%
overall yield from (S)-limonene. The synthesis was accomplished through the convergent …

An enantioselective total synthesis of the labdane diterpene andrographolide, the bitter
principle of the herb Andrographis paniculata (known as “King of Bitters”), was …

A simple Pd/Cu-catalyzed borylation of allenylic carbonates with B2Pin2 was developed
using a cheap P (OEt) 3 ligand. Under mild neutral conditions, 2-boryl 1, 3-butadienes were …

An entirely chromium-free synthesis of eribulin, a fully synthetic macrocyclic ketone
analogue of the marine natural product halichondrin B, was achieved through iterative …

A novel homoallenylboration reaction for the efficient and practical synthesis of valuable
homoallenyl alcohols is presented. This reaction is initiated by the in situ activation of …

A simple approach for the synthesis of the C14–C28 fragment of eribulin has been
developed by employing a one-pot gold-catalyzed alkynol cyclization/Kishi reduction to …

Abstract A new [3+ 2+ 1] annulation strategy based on the heteroatom‐free tri‐atom donor to
synthesize 3, 6‐dihydro‐2H‐pyrans has been developed. In this method, 2‐arylpropylene …

The stereoselective synthesis of C14–C26 fragment of eribulin is reported in a convergent
way by coupling of fragment C14–C19 with fragment C20–C26 that are accessible from …

Metal catalysis with palladium, iridium, and rhodium has provided a lexicon of synthetic
transformations extensively utilized in the construction of complex molecules. The total …