Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …

A guiding principle of biology is that biochemical reactions must be organized in space and
time. One way this spatio-temporal organization is achieved is through liquid–liquid phase …

The amino acid sequences of peptides determine their self-assembling properties. Accurate
prediction of peptidic hydrogel formation, however, remains a challenging task. This work …

Liquid-liquid phase separation (LLPS) has emerged as a crucial biological phenomenon
underlying the sequestration of macromolecules (such as proteins and nucleic acids) into …

In eukaryotes, higher-order chromatin organization is spatiotemporally regulated as
domains, for various cellular functions. However, their physical nature in living cells remains …

In eukaryotic cells, protein and RNA factors involved in genome activities like transcription,
RNA processing, DNA replication, and repair accumulate in self-organizing membraneless …

Genomic DNA is wrapped around a core histone octamer and forms a nucleosome. In
higher eukaryotic cells, strings of nucleosomes are irregularly folded as chromatin domains …

Fundamental features of 3D genome organization are established de novo in the early
embryo, including clustering of pericentromeric regions, the folding of chromosome arms …

Sperm chromatin is typically transformed by protamines into a compact and transcriptionally
inactive state,. Sperm cells of flowering plants lack protamines, yet they have small …

This work reviews nuclear compartments, defined broadly to include distinct nuclear
structures, bodies, and chromosome domains. It first summarizes original cytological …